Each 4 sprays contain: Antim. crud. 5C • Argent. nit. 6C • Arsen. alb. 6C • Carbo veg. 6C • Chelidonium 3X • Colocynthis 6C • Lycopodium 5C • Nat. sulf. 3C • Nux vomica 6C • Podophyllum 5C.
Brand name products often contain multiple ingredients. To read detailed information about each ingredient, click on the link for the individual ingredient shown above.
This is a homeopathic preparation. Homeopathy is a system of medicine established in the 19th century by a German physician named Samuel Hahnemann. Its basic principles are that "like treats like" and "potentiation through dilution." For example, in homeopathy, diarrhea would be treated with an extreme dilution of a substance that normally causes diarrhea when taken in high doses.
Practitioners of homeopathy believe that more dilute preparations are more potent. Many homeopathic preparations are so diluted that they contain little or no active ingredient. Therefore, most homeopathic products are not expected to have any pharmacological effects, drug interactions, or other harmful effects. Any beneficial effects are controversial and cannot be explained by current scientific methods.
Dilutions of 1 to 10 are designated by an "X." So a 1X dilution = 1:10, 3X=1:1000; 6X=1:1,000,000. Dilutions of 1 to 100 are designated by a "C." So a 1C dilution = 1:100; 3C = 1:1,000,000. Dilutions of 24X or 12C or more contain zero molecules of the original active ingredient.
Homeopathic products are permitted for sale in the US due to legislation passed in 1938 sponsored by a homeopathic physician who was also a Senator. The law still requires that the FDA allow the sale of products listed in the Homeopathic Pharmacopeia of the United States. However, homeopathic preparations are not held to the same safety and effectiveness standards as conventional medicines. For more information, see the Homeopathy monograph.
Below is general information about the effectiveness of the known ingredients contained in the product IBS Eze Oral Spray. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the effectiveness of clubmoss.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product IBS Eze Oral Spray. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY UNSAFE ...when used orally. Clubmoss contains toxic alkaloids, but no poisonings have been reported (18).
PREGNANCY AND LACTATION: POSSIBLY UNSAFE
when used orally; avoid using.
UNSAFE ...when used orally (2,13,18,505). Nux vomica in doses of 30-50 mg contains approximately 5 mg of strychnine, and can cause severe adverse effects. 1-2 grams of nux vomica contains 60-90 mg of strychnine, and can be fatal (13,18,65345). Chronic ingestion of lesser amounts can cause death after a period of weeks (18).
PREGNANCY AND LACTATION: UNSAFE
when used orally (2,13,18,505); avoid using.
POSSIBLY SAFE ...when used topically and appropriately, short-term. Treatment areas should be limited to 10 cm2, and only 0.5 mL or less of the resin (podophyllin) should be used due to potential carcinogenic and mutagenic properties. The podophyllum constituent, podophyllotoxin, is safer and has largely replaced podophyllum resin (12897,12902,12903,12904,68936).
LIKELY UNSAFE ...when used orally. Fatalities have been reported from oral ingestion of podophyllum (5617,12898,12900,68924,68944). ...when applied topically in high doses or to large areas, damaged skin, or mucous membranes. Topical application of 5 mL of a 20% solution has caused severe poisoning (12898,12900).
PREGNANCY: LIKELY UNSAFE
when used orally or topically for self-medication; avoid using.
Podophyllum is potentially embryotoxic and teratogenic (12898,12899,68941). Oral and topical use can result in birth defects and fetal death (5618,68937).
LACTATION: LIKELY UNSAFE
when used orally or topically for self-medication (5617); avoid using.
Below is general information about the interactions of the known ingredients contained in the product IBS Eze Oral Spray. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Evidence from in vitro research suggests that clubmoss extract can inhibit acetylcholinesterase activity (43717). Theoretically, concurrent use of clubmoss with other acetylcholinesterase (AChE) inhibitors might have additive effects and increase the risk of cholinergic side effects. AChE inhibitors and cholinergic drugs include bethanechol (Urecholine), donepezil (Aricept), echothiophate (Phospholine Iodide), edrophonium (Enlon, Reversol, Tensilon), neostigmine (Prostigmin), physostigmine (Antilirium), pyridostigmine (Mestinon, Regonol), succinylcholine (Anectine, Quelicin), and tacrine (Cognex).
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Evidence from in vitro research suggests that clubmoss extract can inhibit acetylcholinesterase activity (43717). Theoretically, concurrent use of anticholinergic drugs and clubmoss might decrease the effectiveness of club moss or the anticholinergic agent. Some anticholinergic drugs include atropine, benztropine (Cogentin), biperiden (Akineton), procyclidine (Kemadrin), and trihexyphenidyl (Artane).
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Evidence from in vitro research suggests that clubmoss extract can inhibit acetylcholinesterase activity (43717). Theoretically, concurrent use of clubmoss with other cholinergic drugs might have additive effects and increase the risk of cholinergic side effects. AChE inhibitors and cholinergic drugs include bethanechol (Urecholine), donepezil (Aricept), echothiophate (Phospholine Iodide), edrophonium (Enlon, Reversol, Tensilon), neostigmine (Prostigmin), physostigmine (Antilirium), pyridostigmine (Mestinon, Regonol), succinylcholine (Anectine, Quelicin), and tacrine (Cognex).
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Below is general information about the adverse effects of the known ingredients contained in the product IBS Eze Oral Spray. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, no adverse effects have been reported; however, a thorough evaluation of safety outcomes has not been conducted.
Additionally, clubmoss contains toxic alkaloids, which could cause serious adverse effects (43721). When fir club moss (Lycopodium selago) is mistaken for clubmoss, cholinergic toxicity has been reported. This toxicity is due to huperzine A, which is not present in clubmoss (13193).
Airborne exposure to clubmoss spores might cause symptoms of asthma (43721).
Pulmonary/Respiratory ...Occupational exposure to clubmoss spores, including cases associated with facilities that use the spores to coat condoms, has been reported to cause asthma (43721).
Other ...Clubmoss (Lycopodium clavatum) might be mistaken for fir club moss (Lycopodium selago), which contains huperzine A, a constituent with strong inhibitory activity against acetylcholinesterase. In two case reports, fir club moss was mistaken for clubmoss and ingested as tea. This caused cholinergic toxicity with symptoms of sweating, nausea, dizziness, cramping, and slurred speech (13193).
General ...Orally, 30-50 mg nux vomica (5 mg strychnine) can cause restlessness, feelings of anxiety, heightening of sense perception, enhanced reflexes, equilibrium disorders, painful neck and back stiffness, followed later by twitching, tonic spasms of jaw and neck muscles, painful convulsions of the entire body triggered by visual or tactile stimulation with possible opisthotonos, muscle hypertonicity and agitation. Dyspnea may follow spasm of the respiratory muscles (18). Seizures occur within 15 minutes of ingestion (or 5 minutes of inhalation) and may result in hyperthermia, metabolic and respiratory acidosis, rhabdomyolysis, and myoglobinuric renal failure (17,65345). Nux vomica can be fatal (13,505); most deaths occur 3-6 hours post-ingestion from respiratory and subsequent cardiac arrest, anoxic brain damage, or multiple organ failure secondary to hyperthermia (18,505). Strychnine accumulates with extended administration (2).
Neurologic/CNS ...Orally, 30-50 mg nux vomica (5 mg strychnine) can cause restlessness, feelings of anxiety, heightening of sense perception, enhanced reflexes, equilibrium disorders, painful neck and back stiffness, followed later by twitching, tonic spasms of jaw and neck muscles, painful convulsions of the entire body triggered by visual or tactile stimulation with possible opisthotonos, muscle hypertonicity and agitation. Dyspnea may follow spasm of the respiratory muscles (18). Seizures occur within 15 minutes of ingestion (or 5 minutes of inhalation) and may result in hyperthermia, metabolic and respiratory acidosis, rhabdomyolysis, and myoglobinuric renal failure (17). In one case report, a 58-year old woman developed dizziness with abdominal and leg pain following a seizure, after ingestion of one nux vomica fruit. Her muscles were tense and hyper-reflexive and she had lactic acidosis and nystagmus (65345). Most deaths occur 3-6 hours post-ingestion from respiratory and subsequent cardiac arrest, anoxic brain damage, or multiple organ failure secondary to hyperthermia (18,505). Strychnine accumulates with extended administration, particularly in individuals with liver damage (2).
General
...Orally and topically, podophyllum and its resin (podophyllin) can cause serious adverse effects and is generally regarded as unsafe for use.
Serious Adverse Effects:
Orally and topically: Abdominal pain, bone marrow depression, cardiotoxicity, coma, diarrhea, dyspnea, hallucinations, hepatotoxicity, hypertension or hypotension, kidney failure, metabolic acidosis, paralysis, polyneuropathy, tachycardia, and vomiting. Fatalities have been reported.
Cardiovascular ...Orally and topically, podophyllum resin can cause tachycardia, hypertension or hypotension, and cardiotoxicity (5617,12898,12900).
Dermatologic
...Topically, podophyllum resin can cause severe local irritation and ulcerations (12900,68905).
Topically, the podophyllum constituent podophyllotoxin causes erythema, erosions, burning, pain, itching, and tenderness associated with wart necrosis (12902,12903).
Endocrine ...Orally, chronic use of podophyllum as a cathartic can cause hypokalemia and metabolic alkalosis (5617).
Gastrointestinal
...Orally and topically, podophyllum resin can cause nausea, severe vomiting, diarrhea, abdominal pain, and ileus (5617,12898,12900).
Topically, podophyllum resin applied to the tongue or oral mucosa can cause transient loss of taste and local irritation (12897,68895,68942).
Hematologic ...Orally and topically, podophyllum resin can cause bone marrow depression (5617,12898,12900).
Hepatic ...Orally and topically, podophyllum resin can cause hepatotoxicity (5617,12898,12900).
Neurologic/CNS ...Orally and topically, podophyllum resin can cause polyneuropathy, hallucinations, loss of reflexes, paralysis, and coma (5617,12898,12900).
Pulmonary/Respiratory ...Orally and topically, podophyllum resin can cause tachypnea and dyspnea (5617,12898,12900).
Renal ...Orally and topically, podophyllum resin can cause kidney failure (5617,12898,12900).
Other ...Both oral and topical use of podophyllum resin can be fatal (5617,12898,12900). Topical application of 5 mL of a 20% solution has caused severe poisoning (12898,12900). Symptoms of toxicity usually occur within 13 hours of ingestion or topical application (5617).
