Each ampoule contains: 2-Amino-2-Deoxy-Beta-D-Glucopyranose 1:10 extract (DHE: 130 mg) 1500 mg • Betula alba L. 1:10 extract (DHE: 130 mg solid) 1.3 mL • Filipendula Ulmaria 1:10 extract (DHE: 170 mg) 1.7 mL • Harpagophytum procumbens DC. 1:10 extract (burch pedaliaceae, DHE: 210 mg solid) 2.1 mL • Ribes Nigrum 1:10 extract (DHE: 210 mg) 2.1 mL • Tilia grandifolia 1:10 extract (DHE: 130 mg solid) 1.3 mL. Other Ingredients: Glycerin, Potassium Sorbate, Sodium Benzoate.
Brand name products often contain multiple ingredients. To read detailed information about each ingredient, click on the link for the individual ingredient shown above.
In 2004, Canada began regulating natural medicines as a category of products separate from foods or drugs. These products are officially recognized as "Natural Health Products." These products include vitamins, minerals, herbal preparations, homeopathic products, probiotics, fatty acids, amino acids, and other naturally derived supplements.
In order to be marketed in Canada, natural health products must be licensed. In order to be licensed in Canada, manufacturers must submit applications to Health Canada including information about uses, formulation, dosing, safety, and efficacy.
Products can be licensed based on several criteria. Some products are licensed based on historical or traditional uses. For example, if an herbal product has a history of traditional use, then that product may be acceptable for licensure. In this case, no reliable scientific evidence is required for approval.
For products with non-traditional uses, some level of scientific evidence may be required to support claimed uses. However, a high level of evidence is not necessarily required. Acceptable sources of evidence include at least one well-designed, randomized, controlled trial; well-designed, non-randomized trials; cohort and case control studies; or expert opinion reports.
Finished products licensed by Health Canada must be manufactured according to Good Manufacturing Practices (GMPs) as outlined by Health Canada.
Below is general information about the effectiveness of the known ingredients contained in the product Mobile Plus. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the effectiveness of birch.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
There is insufficient reliable information available about the effectiveness of linden.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Mobile Plus. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY SAFE ...when used orally and appropriately (12). ...when applied topically and appropriately, short-term. Birch bark ointment has been used safely for up to 2 months (35655).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when used orally and appropriately. Black currant juice, leaves, and flowers have Generally Recognized As Safe (GRAS) status in the US (4912). Black currant juice up to 3000 mL daily for up to 3 weeks (17636,35987), black currant extracts 1080 mg daily for 8 weeks (17635,93695), and black currant seed oil products up to 10.5 grams daily for 24 weeks (4016,17634,17638,35990) have also been used safely in clinical research. There is insufficient reliable information about the safety of black currant when used topically.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when used orally and appropriately. Devil's claw extract has been used with apparent safety in doses of up to 2400 mg daily for up 12 weeks (6472,8608,14332,14418,47112,47114,47116,47117,47155). There is insufficient reliable information available about the safety of devil's claw when used orally long-term or when used topically.
PREGNANCY: POSSIBLY UNSAFE
when used orally.
Anecdotal evidence suggests that devil's claw has oxytocic effects in humans. Also, in vitro research shows that moderate to high doses of devil's claw root extract induce contractions of isolated uterine muscle from pregnant and nonpregnant rats (94689); avoid using.
LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when linden leaf is used orally and appropriately in amounts normally found in foods (12). Linden leaf has Generally Recognized as Safe (GRAS) status in the US (4912). There is insufficient reliable information available about the safety of linden when used orally or topically in medicinal amounts.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when used orally and appropriately, short-term (12). Meadowsweet flower has been used with apparent safety at doses of 2.5-3.5 grams daily. Meadowsweet herb has been used with apparent safety at doses of 4-5 grams daily (12).
POSSIBLY UNSAFE ...when used in large amounts or for prolonged periods of time. Meadowsweet contains salicylates and high amounts of tannins (4).
PREGNANCY: LIKELY UNSAFE
when used orally.
Some evidence suggests meadowsweet might stimulate uterine activity (4).
LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Mobile Plus. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, birch might interfere with diuretic therapy (512).
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Theoretically, black currant seed oil might increase the risk of bleeding if used in combination with anticoagulant or antiplatelet drugs.
 Details
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Theoretically, black currant seed oil might increase the risk of seizure in patients receiving phenothiazines.
Details
Black currant seed oil contains gamma-linolenic acid (GLA). There is some concern that taking supplements containing GLA might cause seizures, or lower the seizure threshold, when taken with phenothiazines, although there is no evidence that black currant seed oil causes seizures (88187). In one report, three patients with schizophrenia who had received phenothiazines developed EEG changes suggestive of temporal lobe epilepsy after starting treatment with GLA, although none experienced an actual seizure (21013). In another report, two patients with schizophrenia who were stabilized on phenothiazines developed seizures when evening primrose 4 grams daily, which contains GLA, was added. One of these patients had a prior history of seizures (21010).
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Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C19.
Details
In vitro research shows that devil's claw might inhibit CYP2C19, although this has not been reported in humans (12479).
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Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C9.
Details
In vitro research shows that devil's claw might inhibit CYP2C9, although this has not been reported in humans (12479).
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Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Details
In vitro research shows that devil's claw might inhibit CYP3A4, although this has not been reported in humans (12479).
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Theoretically, devil's claw might decrease the effectiveness of H2-blockers.
Details
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of H2-blockers (19).
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Theoretically, devil's claw might increase levels of P-glycoprotein substrates.
Details
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Theoretically, devil's claw might decrease the effectiveness of PPIs.
Details
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of PPIs (19).
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Theoretically, Devil's claw might increase the activity of warfarin.
Details
In one case report, purpura occurred in a patient taking warfarin and devil's claw concurrently. This might indicate over-anticoagulation (613). It is unclear if this was due to Devil's claw or other contributing factors.
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Theoretically, due to its potential diuretic effects, linden might increase the effects and adverse effects of lithium.
Details
Linden is thought to have diuretic properties (4). The dose of lithium might need to be decreased.
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Theoretically, meadowsweet might have an additive effect with other salicylate-containing drugs, such as aspirin.
Details
Meadowsweet contains salicin, a plant salicylate; however, salicin doesn't seem to have the antiplatelet effects of aspirin (12).
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Theoretically, meadowsweet might have an additive effect with other salicylate-containing drugs, such as choline magnesium trisalicylate (12).
Details
Meadowsweet contains salicin, a plant salicylate (12).
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Theoretically, meadowsweet might have an additive effect with other salicylate-containing drugs such as salsalate (12).
Details
Meadowsweet contains salicin, a plant salicylate (12).
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Below is general information about the adverse effects of the known ingredients contained in the product Mobile Plus. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Birch and birch pollen can cause allergic reactions (12192,35630,35666,97762,97763,97764).
Topically, birch bark, leaves and sap may cause allergic contact dermatitis (35666,97763).
Dermatologic ...Topically, a case of allergic contact dermatitis has been reported for a 51-year-old man who had been applying a cream containing 5% birch bark extract for 4 months prior to the reaction. The constituent betulin was considered to be the most likely cause (97763). Crushed birch leaves and fresh birch sap may also cause allergic contact dermatitis (35666).
Immunologic ...Birch and birch pollen can cause allergic reactions (12192,35630,35666,97762,97763,97764). Treatment of birch pollen allergy can involve immunotherapy with birch pollen extract given sublingually and by the oral vestibular route (97762).
General ...Orally, black currant is generally well-tolerated. Topically, there is a limited amount of information on the adverse effects of black currant.
Gastrointestinal ...Of 2154 patients with hyperlipidemia taking black currant seed oil 1. 8 grams twice daily for 6 weeks, 8 reports of mild diarrhea were considered related to the supplement. These adverse reactions were reported 2-10 days after beginning treatment with black currant seed oil (17638).
General
...Orally, Devil's claw seems to be generally well tolerated.
Most Common Adverse Effects:
Orally: Allergic skin reactions, diarrhea, dyspepsia.
Serious Adverse Effects (Rare):
Orally: Gastrointestinal bleeding.
Cardiovascular ...In one case report, a healthy patient with normal blood pressure presented with hypertension after taking devil's claw 250 mg twice daily for 2 weeks. It gradually resolved after discontinuation of devil's claw (92017). Some animal research shows that devil's claw might have negative chronotropic, as well as positive and negative inotropic, effects (8609). However, these effects have not been documented in humans.
Dermatologic ...Rarely, allergic skin reactions have been reported in patients taking devil's claw (8608,14418).
Endocrine ...In one case report, a 65-year-old female developed psychomotor agitation, nausea, and distress from euvolemic hyponatremia secondary to inappropriate secretion of antidiuretic hormone (SIADH) within 1 month of starting daily treatment with devil's claw. Within 5 days of discontinuing the product and receiving sodium replacement, the symptoms resolved. Two months later, the patient re-initiated devil's claw and again developed euvolemic hyponatremia (96747).
Gastrointestinal ...Gastrointestinal side effects, including mild gastrointestinal upset, diarrhea, anorexia, acid reflux, or loss of taste, have been reported in some individuals receiving devil's claw, especially at high doses (6472,8608,8613,14332,14418,47112,47116,47144,47169). Gastrointestinal complaints have been reported in 9% to 18% of patients taking a specific devil's claw extract (Doloteffin, Ardeypharm) (8608,47169), while diarrhea was reported in about 8% of patients taking devil's claw (Harpadol, Arkopharma) (6472). Several cases of gastrointestinal bleeding have been reported (104977).
Genitourinary ...Dysmenorrhea was reported in one patient taking a specific devil's claw extract (Doloteffin, Ardeypharm) for 8 weeks (8608).
Neurologic/CNS ...In a trial of devil's claw, one patient withdrew after 4 days of therapy due to a throbbing frontal headache, as well as tinnitus, anorexia, and loss of taste (8613). Rarely, dizziness, somnolence, and insomnia have been reported (47116,47169). It is unclear if these symptoms were caused by devil's claw.
Psychiatric ...Rarely, anxiety has been reported in patients taking devil's claw (8608).
General ...There is insufficient reliable information available about the adverse effects of linden.
Cardiovascular ...Frequent consumption of linden tea is thought to be associated with cardiac damage, but this seems to be rare (6).
Immunologic ...Orally, there is one case report of allergic reaction to linden pollen in a linden flower tea (12). Topically, there is one case report of contact urticaria following the use of a linden extract-containing shampoo (12).
General ...Orally, meadowsweet seems to be well tolerated.
Dermatologic ...Meadowsweet contains salicylate constituents. There is insufficient reliable information available to know if the side effects and toxicity normally associated with salicylates could occur with meadowsweet use. Orally, adverse reactions associated with salicin include skin rashes (4).
Gastrointestinal
...Orally, large doses of meadowsweet can cause nausea and other stomach complaints (18).
Meadowsweet contains salicylate constituents. There is insufficient reliable information available to know if the side effects and toxicity normally associated with salicylates could occur with meadowsweet use. Adverse reactions associated with salicylates include gastric irritation, hematochezia, nausea, and vomiting (4).
Immunologic ...Meadowsweet contains salicylate constituents. There is insufficient reliable information available to know if the side effects and toxicity normally associated with salicylates could occur with meadowsweet use. Orally, salicylates can cause hypersensitivity in sensitive individuals (4).
Ocular/Otic ...Meadowsweet contains salicylate constituents. There is insufficient reliable information available to know if the side effects and toxicity normally associated with salicylates could occur with meadowsweet use. Orally, adverse reactions with salicylates include tinnitus (4).
Pulmonary/Respiratory ...Orally, large doses of meadowsweet can cause bronchospastic activity (4).
Renal ...Meadowsweet contains salicylate constituents. There is insufficient reliable information available to know if the side effects and toxicity normally associated with salicylates could occur with the use of meadowsweet. Orally, adverse reactions with salicylates include renal irritation (4).
