Acorus calamus 12 CH. Other Ingredients: Ethyl Alcohol.
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In 2004, Canada began regulating natural medicines as a category of products separate from foods or drugs. These products are officially recognized as "Natural Health Products." These products include vitamins, minerals, herbal preparations, homeopathic products, probiotics, fatty acids, amino acids, and other naturally derived supplements.
In order to be marketed in Canada, natural health products must be licensed. In order to be licensed in Canada, manufacturers must submit applications to Health Canada including information about uses, formulation, dosing, safety, and efficacy.
Products can be licensed based on several criteria. Some products are licensed based on historical or traditional uses. For example, if an herbal product has a history of traditional use, then that product may be acceptable for licensure. In this case, no reliable scientific evidence is required for approval.
For products with non-traditional uses, some level of scientific evidence may be required to support claimed uses. However, a high level of evidence is not necessarily required. Acceptable sources of evidence include at least one well-designed, randomized, controlled trial; well-designed, non-randomized trials; cohort and case control studies; or expert opinion reports.
Finished products licensed by Health Canada must be manufactured according to Good Manufacturing Practices (GMPs) as outlined by Health Canada.
This is a homeopathic preparation. Homeopathy is a system of medicine established in the 19th century by a German physician named Samuel Hahnemann. Its basic principles are that "like treats like" and "potentiation through dilution." For example, in homeopathy, diarrhea would be treated with an extreme dilution of a substance that normally causes diarrhea when taken in high doses.
Practitioners of homeopathy believe that more dilute preparations are more potent. Many homeopathic preparations are so diluted that they contain little or no active ingredient. Therefore, most homeopathic products are not expected to have any pharmacological effects, drug interactions, or other harmful effects. Any beneficial effects are controversial and cannot be explained by current scientific methods.
Dilutions of 1 to 10 are designated by an "X." So a 1X dilution = 1:10, 3X=1:1000; 6X=1:1,000,000. Dilutions of 1 to 100 are designated by a "C." So a 1C dilution = 1:100; 3C = 1:1,000,000. Dilutions of 24X or 12C or more contain zero molecules of the original active ingredient.
Homeopathic products are permitted for sale in the US due to legislation passed in 1938 sponsored by a homeopathic physician who was also a Senator. The law still requires that the FDA allow the sale of products listed in the Homeopathic Pharmacopeia of the United States. However, homeopathic preparations are not held to the same safety and effectiveness standards as conventional medicines. For more information, see the Homeopathy monograph.
Below is general information about the effectiveness of the known ingredients contained in the product Acorus Calamus (Liquid). Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Acorus Calamus (Liquid). Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY UNSAFE ...when used orally. The FDA prohibits calamus use in food products due to evidence of carcinogenic effects in animals receiving high doses of a calamus strain high in beta-asarone (93978,94727,94728). However, the beta-asarone content can vary widely among species from 0% to 96% (6); some products may be safer than others. There is insufficient reliable information available about the safety of calamus when used topically.
PREGNANCY AND LACTATION: LIKELY UNSAFE
when used orally; avoid using (4,500).
Below is general information about the interactions of the known ingredients contained in the product Acorus Calamus (Liquid). Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, taking calamus might reduce the effectiveness of antacids.
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Some research suggests that calamus lowers gastric pH (19).
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Theoretically, concurrent use of anticholinergic drugs and calamus might decrease the effectiveness of the anticholinergic drug.
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In vitro evidence shows that calamus can inhibit acetylcholinesterase (AChE) (38418).
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Theoretically, taking calamus with other antihypertensive medications might increase the risk of hypotension.
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Animal research shows that calamus decreases the rate and strength of the heartbeat, which might lower blood pressure (38444). use with caution.
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Theoretically, concurrent use of cholinergic drugs and calamus might have an additive effect and increase the risk of cholinergic effects.
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In vitro evidence shows that calamus can inhibit acetylcholinesterase (AChE) (38418).
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Theoretically, concurrent use of CNS depressants and calamus might have an additive effect and increase the risk of sedative effects.
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Theoretically, taking calamus with drugs metabolized by CYP2D6 might increase drug levels and potentially increase the risk of adverse effects.
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In vitro research shows that calamus extract inhibits CYP2D6 enzyme (93975).
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Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effects.
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In vitro research shows that calamus extract inhibits CYP3A4 enzyme (93975).
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Theoretically, taking calamus might reduce the effectiveness of H2-blockers.
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Some research suggests that calamus lowers gastric pH (19).
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Theoretically, calamus might potentiate the effects and adverse effects of MAOIs.
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Some reports suggest that calamus increases the effects of MAOIs (4).
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Theoretically, taking calamus might reduce the effectiveness of PPIs.
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Some research suggests that calamus lowers gastric pH (19).
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Below is general information about the adverse effects of the known ingredients contained in the product Acorus Calamus (Liquid). Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...There is currently a limited amount of information on the adverse effects of calamus.
Calamus is likely unsafe for use because it may cause cancer.
Most Common Adverse Effects:
Orally: Nausea, vomiting.
Serious Adverse Effects (Rare):
Orally: Cancer, intestinal paralysis.
Orally, nausea, vomiting, and intestinal paralysis have been reported with calamus use (33310,38458,93980). Tachycardia has also been reported (93980).
Cardiovascular ...Tachycardia has been reported as a toxic effect related to oral use of calamus oil (93980).
Gastrointestinal ...A case of gastrointestinal toxicity has been reported in a 19-year-old male who appeared to use calamus root for its euphoric effects. The man ingested a large amount of the root with water and later presented at the emergency department with continuous vomiting, paleness, and sweating. He was treated intravenously with saline and promethazine (38458). Both nausea and vomiting have been reported in patients using calamus oil orally (93980). Intestinal paralysis has also been reported with calamus use in children (33310).
Oncologic ...Beta-asarone, a constituent of calamus, increases the risk of cancer (93978,94727,94728).
