Two vegetarian capsules contain: Strontium (as strontium citrate) 680 mg. Other Ingredients: Kosher Hypromellose (vegetarian capsule), Cellulose, Magnesium Stearate.
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Below is general information about the effectiveness of the known ingredients contained in the product Strontium 680 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Strontium 680 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when consumed orally in food amounts. Strontium has not been linked to toxicity when consumed in dietary amounts, which are typically about 0.5-1.5 mg daily (14554,14560). ...when strontium-89 chloride is used intravenously and appropriately. Strontium-89 chloride is an FDA-approved product (4948). ...when strontium chloride is used topically and appropriately as a toothpaste. Strontium chloride hexahydrate (Sensodyne-SC) is an FDA-approved product (9).
POSSIBLY SAFE ...when strontium ranelate is used orally and appropriately. Strontium ranelate 2 grams daily, providing elemental strontium 680 mg daily, seems to be safe when used for up to 10 years (11392,11393,11395,14549,94012).
POSSIBLY UNSAFE ...when used orally in high doses. Very high doses may adversely affect bone structure, although data in humans is limited (11394,11399,14554,14556). Until more is known, advise patients to avoid doses of elemental strontium above 680 mg/day. There is insufficient reliable information available about the safety of strontium chloride, the form most commonly used in dietary supplements, when used orally.
PREGNANCY AND LACTATION: LIKELY SAFE
when consumed orally in food amounts.
Strontium has not been linked to toxicity when consumed in dietary amounts, which are typically about 0.5 mg to 1.5 mg/day (14554,14560). ...when strontium chloride is used topically and appropriately as a toothpaste (9). Strontium chloride hexahydrate (Sensodyne-SC) is an FDA approved product.
PREGNANCY AND LACTATION: LIKELY UNSAFE
when strontium-89 chloride is used during pregnancy or lactation.
Strontium-89 chloride is a radioactive isotope which may cause fetal harm. It is FDA pregnancy risk category D; avoid using (11755). Since strontium behaves similarly to calcium in the body, strontium-89 is likely to be excreted into breast milk; avoid using during lactation (11755). There is insufficient reliable information about the safety of oral strontium when used in amounts exceeding typical dietary intake during pregnancy or lactation; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Strontium 680 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, androgens might reduce the excretion of strontium, potentially increasing its effects and adverse effects.
 Details
A small clinical study suggests that treatment with androgens such as testosterone, nandrolone, oxandrolone, and oxymetholone for 5-6 weeks might decrease urinary strontium excretion (11405). The clinical significance of this interaction is unknown.
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Antacids can reduce the absorption of strontium, potentially decreasing its effectiveness.
Details
Aluminum hydroxide and magnesium hydroxide can reduce absorption of strontium ranelate by 20% to 25%. Calcium can reduce its absorption to 60% to 70%. Avoid taking antacids within 2 hours of a dose of strontium ranelate (14549,25056). This interaction has also been reported with orally-administered radioactive strontium-85 (14554). It will likely also occur with other forms of strontium.
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Theoretically, estrogens might reduce the excretion of strontium, potentially increasing its effects and adverse effects.
Details
A small clinical study suggests that treatment with estrogens for 5-6 weeks might decrease urinary strontium excretion (11405). The clinical significance of this interaction is unknown.
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Theoretically, strontium might decrease the absorption of quinolone antibiotics.
Details
Strontium is a divalent cation with similar properties to calcium. It is likely to form complexes with quinolones in the gastrointestinal (GI) tract, preventing absorption of the antibiotic (14549). Recommend taking strontium supplements at least 2 hours before or after quinolones to avoid an interaction.
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Theoretically, strontium might decrease the absorption of tetracycline antibiotics.
Details
Strontium is a divalent cation with similar properties to calcium. It is likely to form complexes with tetracyclines in the gastrointestinal (GI) tract, preventing absorption of the antibiotic (14549). Recommend taking strontium supplements at least 2 hours before or after tetracyclines to avoid an interaction.
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Below is general information about the adverse effects of the known ingredients contained in the product Strontium 680 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, strontium ranelate seems to be well tolerated when used in doses up to 2 grams (680 mg elemental strontium) daily, long-term.
Most Common Adverse Effects:
Orally: Atopic dermatitis, diarrhea, headache, nausea.
Serious Adverse Effects (Rare):
Orally: Myocardial infarction, osteomalacia, venous thromboembolism.
Cardiovascular ...Orally, clinical research shows that strontium ranelate increases the relative risk of venous thromboembolism and pulmonary embolism by about 50% compared with placebo (14561,14562). The reason for this is unknown. Strontium ranelate also seems to increase the risk of myocardial infarction by about 1.6-fold in patients with osteoporosis (95699).
Dermatologic ...Orally, common side effects of strontium ranelate can include dermatitis and eczema (11392,11393,11395,14549).
Gastrointestinal ...Orally, strontium ranelate can cause stomach pain, diarrhea, and nausea, particularly at higher doses (14561,76541,94010,94012).
Hematologic ...Intravenously, strontium-89 causes bone marrow toxicity, particularly affecting platelet and white blood cell counts. Platelet levels fall by about 30% and the nadir is generally 12 to 16 weeks after injection. The effect on white blood cells is variable. Blood cell counts generally recover slowly over a period of about 6 months (11752,11755).
Musculoskeletal ...There is some concern that doses of strontium higher than those used in clinical trials may adversely affect bone by impairing mineralization and reducing calcium absorption, leading to abnormal skeletal development and reduced bone quality (11394,11399,14554,14557). This would manifest as rickets if it occurs during bone growth, and as osteomalacia after growth is complete (14556). The concern is mainly based on animal data, although strontium-related rickets has been observed in children eating plant-derived foods grown in locations with high soil strontium levels (>350 ppm), especially if they also have inadequate protein, calcium, and vitamin D intake (11399,14554,14556,14557). Accumulation of strontium has also been reported in people with end-stage renal disease, especially those on dialysis, and has been linked to osteomalacia in such patients. Elevated serum and bone strontium levels seem to occur more commonly in patients with osteomalacia than in those with other types of renal osteodystrophy or no bone changes. Strontium is thought to accumulate due to reduced renal excretion and also the presence of strontium in dialysis fluids (14554,14555,14557,14559).
Neurologic/CNS ...Orally, strontium ranelate has reportedly caused altered consciousness, memory loss, and seizures on occasion (14549).
