BioChoice Immune26 Packets [Discontinued] by Legacy for Life

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Athletic performance. Preliminary clinical research in recreationally active young men shows that taking hyperimmune egg (Immune26, Legacy for Life) orally in a dose of 4.5 grams daily for 2 days, then 9 grams daily for 2 days, then 13.5 grams daily for 6 days, reduces the maximum heart rate and increases peak power during three 5-minute submaximal exercise bouts on a treadmill when compared with placebo (102905). Poor study design limits the reliability of this research.
• Cystic fibrosis. Preliminary clinical research in cystic fibrosis patients aged 2-32 years who have had a prior infection with Pseudomonas aeruginosa shows that using a hyperimmune egg yolk extract containing 50 mg of IgY antibodies to two strains of P. aeruginosa as a gargle once daily at bedtime, and then swallowing the liquid, prolongs the time to the second infection when compared with patients who do not receive the gargle (102908). During follow-up of 36-92 months (mean 57 months), patients using the gargle had 2.5 positive sputum cultures for P. aeruginosa per 100 months of observation, compared with 13.7 per 100 months in the untreated control group. In the treated group, no patients became chronically colonized with the organism, compared with 24% of patients in the control group (102908). In further follow-up lasting up to 12 years, the treated patients were switched to an egg extract containing 50 mg of IgY antibodies against six strains of P. Aeruginosa, which was used as a gargle for 2 minutes once daily and swallowed. There were 2.3 positive sputum cultures per 100 months of observation, and 2 patients developed chronic colonization with P. aeruginosa. In the untreated control group, there were 7 positive sputum cultures per 100 months, and 7 patients became chronically colonized (102909). The reliability of this research is reduced by lack of randomization, since treated patients from Sweden were compared with untreated patients from Denmark. Additionally, some, but not all, of the evaluated patients were receiving chronic treatment with azithromycin.
• Helicobacter pylori. Preliminary clinical research shows that taking a specific defatted egg powder product prepared from eggs of hens immunized with Helicobacter pylori urease (Ovlagen, GHEN Corp., Japan), 900 mg three times daily after meals for 4 weeks, is associated with a reduction in urea breath test values, but not complete eradication of H. pylori, in asymptomatic volunteers with H. pylori-positive urea breath tests (102910). Other clinical research shows that taking a yogurt drink containing H. pylori urease-specific IgY 15 mg, Lactobacillus acidophilus, and Bifidobacterium species, 150 mL three times daily for 4 weeks, is associated with a 40% reduction in urea breath test values when compared with baseline in volunteers positive for H. pylori by urea breath test. Taking the same yogurt drink without IgY is associated with a 15% reduction in urea breath test values when compared with baseline (102911). The validity of this finding is limited by the lack of a direct comparison to the control group.
• Hyperlipidemia. Preliminary clinical research shows that taking a specific hyperimmune egg powder formulation (Immune26, Legacy for Life) for 26 weeks does not significantly lower cholesterol when compared with baseline (13213). The validity of this finding is limited by the lack of a comparator group.
• Osteoarthritis. Preliminary clinical research shows that some patients with osteoarthritis might have reduced subjective measures of joint pain or swelling after taking a specific hyperimmune egg powder formulation (Immune26, Legacy for Life) for 2 months when compared with baseline (13207). Poor study design limits the reliability of this research.
• Periodontitis. Preliminary clinical research shows that using lozenges containing hyperimmune egg yolk immunoglobulin (IgY) from hens immunized with Porphyromonas gingivalis proteinases (gingipains) reduces gingival bleeding index and oral P. gingivalis counts more than placebo in people with periodontitis. Two lozenges, each containing 12 mg powdered IgY, were dissolved in the mouth 3 times daily after meals for 8 weeks (102902).
• Rheumatoid arthritis (RA). Preliminary clinical research shows that taking a specific hyperimmune egg powder formulation (Immune26, Legacy for Life) for 2 months does not significantly improve subjective measures of RA symptoms when compared with baseline (13207). Poor study design limits the reliability of this research.
• Rotaviral diarrhea. Preliminary clinical research shows that taking a preparation of purified egg yolk immunoglobin (IgY) from hens immunized against strains of rotavirus, 10 grams daily in 4 divided doses for 4 days, can modestly decrease rotaviral diarrhea in children aged 2-24 months. The IgY preparation seems to significantly reduce stool output and oral rehydration solution intake on day 1 of treatment. But it does not seem to significantly reduce stool on subsequent days. Children treated with the IgY also seem to clear rotavirus from the stool more quickly when compared with children receiving placebo (13206). More evidence is needed to rate hyperimmune egg for these uses.

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POSSIBLY SAFE ...when used orally and appropriately. A specific commercial hyperimmune egg product (Immune26, Legacy for Life) has been used with apparent safety in studies lasting up to 26 weeks (13207,13213). A hyperimmune egg product containing antibodies against Helicobacter pylori has been used with apparent safety for 4 weeks (102910,102911). A hyperimmune egg product containing antibodies against Pseudomonas aeruginosa has been used with apparent safety in a limited number of adult patients with cystic fibrosis for up to 12 years (102908,102909).

CHILDREN: POSSIBLY SAFE
when used orally and appropriately. A hyperimmune egg extract containing antibodies against rotavirus has been used with apparent safety in children aged 2-24 months for 4 days (13206). A hyperimmune egg product containing antibodies against Pseudomonas aeruginosa has been used with apparent safety in children aged 1-18 years with cystic fibrosis for up to 12 years (102908,102909).

PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.

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General ...Orally, hyperimmune egg seems to be well tolerated when used short-term. Side effects reported in clinical trials include gastrointestinal effects and skin rash (13213,102904).

Dermatologic ...Orally, skin rash has been reported in one clinical trial, but did not require treatment (102904).

Gastrointestinal ...Orally, hyperimmune egg products have been reported to cause diarrhea, gas, stomach ache, and bloating (13213,102904).

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