Anabolic Elite [Discontinued] by BPI

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Crohn disease. Observational research over a period of 24-28 days in a small group of patients with active inflammatory bowel disease (50% ulcerative colitis and 50% Crohn disease) suggests that taking a specific combination product containing coffee charcoal 50 mg, myrrh 100 mg, and chamomile extract 70 mg per tablet (MYRRHINIL-INTEST, Repha GmbH) results in symptom resolution in 16-26 days. The probability of being free of symptoms did not differ between patients using other treatments, the coffee charcoal product alone, or a combination of the coffee charcoal product with other treatments. Overall efficacy was rated as good to very good by patients and physicians (104593). The effect of coffee charcoal alone is unclear.
• Diarrhea. Observational research over a period of 7-14 days in a group of patients with active diarrhea related to an acute inflammatory disorder suggests that taking a specific combination product containing coffee charcoal 50 mg, myrrh 100 mg, and chamomile extract 70 mg per tablet (MYRRHINIL-INTEST, Repha GmbH), alone or in combination with other therapies, improves overall symptoms of diarrhea. The median time to symptom resolution was 4 days. The probability of symptom resolution with use of the coffee charcoal combination product was similar to that observed when other treatments were used. Overall efficacy was rated as good to very good by patients and physicians (104593). The effect of coffee charcoal alone is unclear.
• Irritable bowel syndrome (IBS). Observational research over a period of 24-28 days in a group of patients with IBS suggests that taking a specific combination product containing coffee charcoal 50 mg, myrrh 100 mg, and chamomile extract 70 mg per tablet (MYRRHINIL-INTEST, Repha GmbH), alone or in combination with other therapies, improves overall symptoms of diarrhea. The probability of being free of symptoms did not differ between patients using other treatments or when the coffee charcoal combination product was used in combination with other treatments. Overall efficacy was rated as good to very good by patients and physicians (104593). The effect of coffee charcoal alone is unclear.
• Ulcerative colitis. Preliminary clinical research shows that taking a specific combination product containing coffee charcoal 50 mg, myrrh 100 mg, and chamomile extract 70 mg per tablet (MYRRHINIL-INTEST, Repha GmbH) four tablets three times daily for 12 months is non-inferior to mesalamine therapy for maintaining remission in patients with inactive ulcerative colitis (93653). In addition, observational research over a period of 24-28 days in a small group of patients with active inflammatory bowel disease (50% ulcerative colitis and 50% Crohn disease) suggests that taking this same product results in symptom resolution in 16-26 days. The probability of being free of symptoms did not differ between patients using other treatments, the coffee charcoal product alone, or a combination of the coffee charcoal product with other treatments. Overall efficacy was rated as good to very good by physicians (104593). The effect of coffee charcoal alone is unclear. More evidence is needed to rate coffee charcoal for these uses.

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INSUFFICIENT RELIABLE EVIDENCE to RATE

• Cancer. Although there has been interest in using topical gentian for cancer, there is insufficient reliable information about the clinical effects of gentian for this purpose.
• Diabetes. Although there has been interest in using oral gentian for diabetes, there is insufficient reliable information about the clinical effects of gentian for this purpose.
• Diarrhea. Although there has been interest in using oral gentian for diarrhea, there is insufficient reliable information about the clinical effects of gentian for this purpose.
• Flatulence. Although there has been interest in using oral gentian for flatulence, there is insufficient reliable information about the clinical effects of gentian for this purpose.
• Gastritis. Although there has been interest in using oral gentian for gastritis, there is insufficient reliable information about the clinical effects of gentian for this purpose.
• Gastroesophageal reflux disease (GERD). Although there has been interest in using oral GERD for diarrhea, there is insufficient reliable information about the clinical effects of gentian for this purpose.
• Hypertension. Although there has been interest in using oral gentian for hypertension, there is insufficient reliable information about the clinical effects of gentian for this purpose.
• Malaria. Although there has been interest in using oral gentian for malaria, there is insufficient reliable information about the clinical effects of gentian for this purpose.
• Obesity. It is unclear if oral gentian is beneficial for obesity. Details: Preliminary clinical research in healthy adults shows that consuming a pudding containing microencapsulated gentian root extract 1.25 g at breakfast modestly reduces caloric intake over 24 hours, but does not affect self-reported feelings of hunger or fullness, when compared with placebo pudding (96534).
• Rhinosinusitis. Oral gentian has only been evaluated in combination with other ingredients; its effect when used alone is unclear. Details: Clinical research shows that taking a specific combination product (SinuComp; Sinupret) that contains gentian root 6 mg , elderflower, verbena, cowslip flower, and sorrel improves the symptoms of acute or chronic sinusitis when compared with placebo (374,379). Observational research in adults with acute rhinosinusitis suggests that taking the same combination product orally three times daily, in addition to topical mometasone furoate nasal spray, for 7 days is associated with lower symptom scores when compared with mometasone nasal spray alone (95907).
• Wound healing. Although there has been interest in using topical gentian for wound healing, there is insufficient reliable information about the clinical effects of gentian for this purpose. More evidence is needed to rate gentian for these uses.

(Read more about GENTIAN)

POSSIBLY SAFE ...when used orally and appropriately (2). In clinical research, a specific combination product providing coffee charcoal 600 mg, myrrh 1200 mg, and chamomile extract 840 mg (MYRRHINIL-INTEST, Repha GmbH) daily has been safely used for up to 12 months (93653). ...when used topically and appropriately (2).

PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.

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LIKELY SAFE ...when the root preparations are used in amounts commonly found in foods. Gentian root is categorized by the FDA as a safe food additive flavoring in the US (4912).

POSSIBLY SAFE ...when gentian root is used orally in a specific combination that contains gentian root, elderflower, verbena, cowslip flower, and sorrel (SinuComp, Sinupret) (374,379,95907). There is insufficient reliable information available about the safety of the topical use of gentian.

PREGNANCY AND LACTATION:
There is insufficient reliable information available about the safety of gentian in medicinal amounts during pregnancy and lactation; avoid using.

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ANTIHYPERTENSIVE DRUGS Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.  Details In vitro research shows that gentian can cause vasodilation and lower blood pressure (13439,13441).

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General ...Orally, coffee charcoal seems to be well tolerated (2,93653). However, a thorough evaluation of safety outcomes has not been conducted. In clinical studies, a combination product containing coffee charcoal, myrrh, and chamomile extract (MYRRHINIL-INTEST, Repha GmbH) has been used for up to 12 months without reported adverse effects (93653,104593).

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General ...Orally, gentian root, in combination with other herbs, seems to be generally well tolerated. There is insufficient reliable information available about the adverse effects of gentian when taken as a medicine alone.
Most Common Adverse Effects:
Orally: Allergic skin reactions, gastrointestinal discomfort.

Gastrointestinal ...Orally, gentian root, in combination with other herbs, has been reported to cause gastrointestinal adverse effects (374,379). Gastrointestinal intolerance occurred in patients with cancer-associated anorexia who took gentian tincture 1 mL three times daily, in conjunction with turmeric 1 gram and ginger 1 gram twice daily, for 14 days. Six of 17 patients discontinued the regimen due to nausea, 3 due to vomiting, 2 due to diarrhea, and 2 due to bloating. It is unclear if this gastrointestinal intolerance was caused by gentian, the other herbs, or the patients' predisposing conditions (96263).

Immunologic ...Orally, gentian root, in combination with other herbs, has been reported to cause allergic skin reactions (374,379). It is unclear if these reactions were caused by gentian, the other herbs, or the combination.

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