| Ingredients | Not Present |
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infusions (1:6000) of
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(Prunus cerasifera )
(flowers)
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(Clematis vitalba )
(flowers)
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Impatiens glandulifera
(Impatiens glandulifera )
(flowers)
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(Helianthemum nummularium )
(flowers)
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(Ornithogalum umbellatum )
(flowers)
(wild-harvested in Britain)
(Ornithogalum umbellatum PlantPart: flowers Genus: Ornithogalum Species: umbellatum Note: wild-harvested in Britain )
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Water, Brandy Note: Organic and Biodynamic
Below is general information about the effectiveness of the known ingredients contained in the product Five-Flower Formula. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
There is insufficient reliable information available about the effectiveness of rock rose.
There is insufficient reliable information available about the effectiveness of star of Bethlehem.
There is insufficient reliable information available about the effectiveness of traveler's joy.
Below is general information about the safety of the known ingredients contained in the product Five-Flower Formula. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY SAFE ...when used orally and appropriately, short-term. Jambolan tea prepared from 2 grams of jambolan leaves per liter of water has been consumed in place of water with apparent safety in clinical research (13092).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
There is insufficient reliable information available about the safety of rock rose.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY UNSAFE ...when used orally. Star of Bethlehem contains toxic cardiac glycosides (15330,15331,15332,15333). Ingestion of star of Bethlehem could result in serious adverse effects including cardiac arrhythmia and death.
PREGNANCY AND LACTATION: LIKELY UNSAFE
when used orally.
Star of Bethlehem contains toxic cardiac glycosides (15330,15331,15332,15333). Ingestion of star of Bethlehem could result in serious adverse effects.
LIKELY UNSAFE ...when used orally or topically due to the constituent protoanemonin, which is a severe local irritant (18).
PREGNANCY AND LACTATION: LIKELY UNSAFE
when used orally or topically (18).
Below is general information about the interactions of the known ingredients contained in the product Five-Flower Formula. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels (13599,13600,13601,104282). Theoretically, jambolan might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.
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There is some in vitro evidence that jambolan can inhibit CYP2C9 (99067). Theoretically, concomitant use of jambolan with CYP2C9 substrates may increase levels of drugs metabolized by CYP2C9.
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Animal research shows that jambolan seed extract reduces the sitagliptin maximum plasma concentration and area under the curve by 39% and 22%, respectively. However, blood glucose levels were actually reduced to a greater extent in mice taking jambolan and sitagliptin in combination when compared with either product taken alone (104282). Theoretically, jambolan seed extract might alter the clearance of sitagliptin, although this may not alter the clinical effects of sitagliptin.
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Theoretically, taking star of Bethlehem with prolonged corticosteroid therapy might increase the risk of toxicity.
 Details
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Theoretically, taking star of Bethlehem in combination with digoxin might have additive effects and increase the risk of toxicity.
Details
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Theoretically, taking diuretics with star of Bethlehem might increase the risk of toxicity.
Details
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Theoretically, taking macrolide antibiotics with star of Bethlehem might increase the risk of cardiac glycoside toxicity.
Details
Star of Bethlehem contains cardiac glycosides (15330,15331). Macrolide antibiotics appear to increase the gastrointestinal absorption of oral digoxin. Theoretically, concomitant use of macrolide antibiotics might increase the absorption of the cardiac glycosides found in star of Bethlehem and increase the risk of adverse effects (17).
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Theoretically, taking quinine with star of Bethlehem might increase the risk of cardiac glycoside toxicity.
Details
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Theoretically, excessive use of stimulant laxatives with star of Bethlehem might increase the risk of toxicity.
Details
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Theoretically, taking tetracycline antibiotics with star of Bethlehem might increase the risk of cardiac glycoside toxicity.
Details
Star of Bethlehem contains cardiac glycosides similar to digitalis (15330,15331). Tetracycline antibiotics appear to increase the gastrointestinal absorption of oral digoxin. Theoretically, concomitant use of tetracycline antibiotics might increase the absorption of the cardiac glycosides found in star of Bethlehem and increase the risk of adverse effects (17).
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Below is general information about the adverse effects of the known ingredients contained in the product Five-Flower Formula. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General ...No adverse effects have been reported; however, a thorough evaluation of safety outcomes has not been conducted.
General ...No adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted.
General
...Star of Bethlehem contains cardiac glycosides, which can cause serious adverse effects.
Serious Adverse Effects (Rare):
Orally: Star of Bethlehem contains toxic cardiac glycosides that can cause cardiac arrhythmia and death.
Cardiovascular ...Orally, the cardiac glycosides in star of Bethlehem can cause cardiac arrhythmias (2).
Gastrointestinal ...Orally, the cardiac glycosides in star of Bethlehem can cause nausea and vomiting (2).
Neurologic/CNS ...Orally, the cardiac glycosides in star of Bethlehem can cause headache and stupor (18). Visual color disturbances can also occur (18).
General
...Orally, traveler's joy can cause severe irritation of the gastrointestinal tract, including colic and diarrhea.
Irritation of the urinary tract can also occur.
Topically, skin contact can cause blisters and burns that are difficult to heal (18).
