Broad-Spectrum CBD Oil 10 mg Lemon Flavored by Bluebird Botanicals

POSSIBLY EFFECTIVE

• Atopic dermatitis (eczema). Topical coconut oil has been evaluated for the management of atopic dermatitis in children, with promising results. Details: One clinical trial in children with atopic dermatitis shows that topical application of virgin coconut oil 5 mL twice daily for 8 weeks results in moderate or excellent improvements in almost two-fold more patients and reduces symptom severity about 30% when compared with mineral oil (90614).
• Prematurity. Topical coconut oil may reduce the risk for hypothermia and apnea and improve body weight, length, and skin integrity in premature infants. Details: A large clinical study in premature infants shows that applying coconut oil 5 mL topically four times daily for 28 days reduces the incidence of hypothermia and apnea by 67% and 76%, respectively, when compared with body massage without oil. There were also improvements in the level of vitamin D3 and the overall neurodevelopmental score over 12 months (101873). Clinical studies in premature infants also show that oil massage using coconut oil reduces weight loss in the first few days after birth and improves weight gain and length when compared with mineral oil or no application (17937,90616,101873). Preterm infants are at increased risk for infection due to the inadequate protective barrier provided by immature skin. Clinical studies in preterm or very preterm infants show that topical application of virgin coconut oil 2-4 times daily for 21-28 days as part of routine neonatal care helps maintain skin integrity, but does not reduce the risk for infections such as sepsis, when compared with routine neonatal care alone (96204,101873). Another clinical study in preterm infants shows that topical application of coconut oil 5 mL/kg twice daily for 28 days reduces the incidence of hospital-acquired infections from 21% to 7% when compared with control, but does not reduce overall mortality (90616).

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Alzheimer disease. Although there has been interest in using oral coconut oil for Alzheimer disease, there is insufficient reliable information about the clinical effects of coconut oil for this purpose.
• Athletic performance. It is unclear if oral coconut oil is beneficial for improving athletic performance. Details: A small clinical trial in recreational runners shows that taking virgin coconut oil (Copra Alimentos, Maceio) 15 grams, with or without caffeine 6 mL/kg, 60 minutes prior to a 1600 meter running trial does not improve running performance or ratings of exertion when compared with a warm water control (101874).
• Breast cancer. It is unclear if oral coconut oil is beneficial in patients with breast cancer. Details: A small clinical study in patients with invasive or advanced breast cancer shows that taking virgin coconut oil 10 mL twice daily starting one week after chemotherapy from the third to the sixth cycle improves quality of life based on some but not all measurement scales when compared with control (90615).
• Coronary heart disease (CHD). Small clinical studies suggest that oral coconut oil does not alter the risk of CHD or prevent cardiovascular events in patients with CHD. Details: One small observational study in India has found that coconut or coconut oil consumption is not associated with a decreased or increased risk of myocardial infarction or angina (14407). A small clinical trial in patients with CHD from India shows that cooking with coconut oil does not alter cardiovascular outcomes or risk factors at 6 months, 1 year, or 2 years when compared with cooking with sunflower oil (96205).
• Coronavirus disease 2019 (COVID-19). Although there has been interest in using oral coconut oil for COVID-19, there is insufficient reliable information about the clinical effects of coconut oil for this purpose.
• Crohn disease. Although there has been interest in using oral coconut oil for Crohn disease, there is insufficient reliable information about the clinical effects of coconut oil for this purpose.
• Dental plaque. Small clinical studies suggest that pulling coconut oil through the teeth may modestly reduce dental plaque. Details: A small clinical study shows that pulling coconut oil 10 mL through the teeth for 15-20 minutes twice daily for 4 days is as effective as using a mouth rinse containing chlorhexidine gluconate-0.2% as 10 mL twice daily for 30 seconds in the prevention of plaque regrowth in posterior, but not anterior, surfaces of the teeth (101878). Another small clinical study in patients with plaque-induced gingivitis shows that pulling coconut oil 10 mL through the teeth for 5-10 minutes nightly for 30 days improves plaque scores when compared with standard dental hygiene with no mouth rinse (106491).
• Diabetes. It is unclear if oral coconut oil is beneficial for diabetes. Details: A meta-analysis of clinical trials shows that a single intake of coconut oil as part of a meal modestly increases postprandial glucose levels and decreases insulin levels. However, long-term intake of coconut oil increases insulin resistance, with no effect on fasting blood glucose or insulin levels. Only two studies in these analyses included patients with diabetes (107667). Therefore, the effect of coconut oil in patients with diabetes is unclear.
• Diarrhea. It is unclear if oral coconut oil is beneficial for improving diarrhea in children. Details: One small clinical study in children with mild-to-moderate dehydration due to diarrhea shows that eating a diet consisting of coconut oil, chicken, and plantain reduces the duration of diarrhea by 20 hours when compared with a cow's milk diet (19269). However, another small clinical trial in children with acute gastroenteritis shows that total duration of diarrhea is no different in children given a milk-free formula containing coconut oil when compared with children given cow's milk formula (19270).
• Dry mouth. It is unclear if topical coconut oil is beneficial for improving dry mouth in patients receiving radiation therapy. Details: One small clinical study in patients with dry mouth caused by radiation therapy shows that coating the mouth with coconut oil prior to meals and at bedtime for 2 weeks does not improve dry mouth-related quality of life scores when compared to baseline (106490).
• Dry skin. It is unclear if topical coconut oil is beneficial for improving dry skin. Details: A small clinical study in patients with mild-to-moderate dry skin shows that applying coconut oil topically twice daily improves skin moisture and skin lipid levels when compared to baseline. Coconut oil seems to be comparable to mineral oil as a skin moisturizer (17936). Also, preliminary clinical research in individuals who apply alcohol-based sanitizers to the hands six times daily shows that applying 6-8 drops (0.1 mL/cm²) of virgin coconut oil to the hands before bed for 15 days modestly increases perceived moisture content, but not perceived appearance or sensation, when compared with not using coconut oil (107668).
• Fetal and premature infant mortality. It is unclear if topical coconut oil is beneficial for reducing mortality in premature infants. Details: One clinical study in preterm infants shows that topical application of coconut oil 5 mL/kg twice daily for 28 days reduces the incidence of hospital-acquired infections from 21% to 7% when compared with control, but does not reduce overall mortality (90616).
• Gingivitis. It is unclear if pulling coconut oil through the teeth is beneficial in patients with gingivitis. Details: A small clinical study in patients with plaque-induced gingivitis shows that pulling coconut oil 10 mL through the teeth for 5-10 minutes nightly for 30 days improves gingival bleeding scores when compared with standard dental hygiene without a mouth rinse (106491). Another small clinical study in volunteers with gingival inflammation shows that pulling extra virgin coconut oil, 5 mL, through the teeth for 8 minutes daily for 28 days does not change plaque microbial counts when compared with baseline or with palm oil pulling (110010).
• HIV/AIDS. Although there has been interest in using oral coconut oil for HIV/AIDS, there is insufficient reliable information about the clinical effects of coconut oil for this purpose.
• Hypertension. It is unclear if oral coconut oil is beneficial in patients with hypertension. Details: One small clinical study in patients with hypertension shows that taking extra virgin coconut oil 3 mL with breakfast, 4 mL with lunch, and 3 mL with dinner daily for 30 days does not reduce blood pressure when compared with placebo (106493).
• Irritable bowel syndrome (IBS). Although there has been interest in using oral coconut oil for IBS, there is insufficient reliable information about the clinical effects of coconut oil for this purpose.
• Lice. Topical coconut oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear. Details: One clinical study in children with head lice shows that application of a topical spray containing coconut oil, anise oil, and ylang ylang oil (Chick-Chack) once every 5 days for three treatments eradicates lice in around 92% of infected children, a rate comparable to children treated with a spray containing permethrin, malathion, piperonyl butoxide, and isododecane (13483). It is unclear if these findings are due to coconut oil, other ingredients, or the combination.
• Low birth weight. It is unclear if oral coconut oil is beneficial for improving growth in infants with very low birth weight. Details: One small, open-label clinical trial in very low birth weight infants shows that giving coconut oil 1 mL four times daily in expressed breast milk until 40 weeks corrected age does not increase growth when compared with breast milk alone. The addition of coconut oil also has no effect on head circumference, length, weight, or body fat improvements (101875).
• Metabolic syndrome. It is unclear if oral coconut oil is beneficial in patients with metabolic syndrome. Details: One small clinical trial in patients with metabolic syndrome shows that using 30 mL of virgin coconut oil in place of other cooking oils daily for 4 weeks reduces levels of triglycerides, very low-density lipoprotein (VLDL) cholesterol, and fasting plasma glucose and increases high-density lipoprotein (HDL) cholesterol levels when compared with a usual diet. However, levels of total cholesterol and low-density lipoprotein (LDL) cholesterol were increased with coconut oil use. Coconut oil did not alter blood pressure or waist circumference (106494).
• Multiple sclerosis (MS). Oral coconut oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear. Details: One small clinical study in patients with MS shows that taking coconut oil 60 mL in combination with epigallocatechin gallate (EGCG) 800 mg daily for 4 months improves functional capacity, increases muscle mass, and reduces symptoms of anxiety and depression by a small amount when compared to baseline (101876,106492). It is unclear if these findings are due to coconut oil, EGCG, or the combination. Additionally, the validity of these findings is limited by the lack of a comparator group.
• Nipple fissures. It is unclear if topical coconut oil is beneficial for nipple fissures in breastfeeding mothers. Details: Preliminary clinical research in breastfeeding primiparous mothers with nipple fissures shows that applying 0.5 mL of virgin coconut oil to the fissures after breastfeeding three times daily for 14 days improves scores on Storr's fissure scale and on a visual analog pain scale, when compared with applying 3 to 4 drops of breastmilk to the nipples after every breastfeeding session (110407).
• Nocturnal enuresis. It is unclear if topical coconut oil is beneficial in children with primary nocturnal enuresis. Details: Preliminary clinical research in children aged 6 to 14 years with primary nocturnal enuresis shows that applying coconut oil, 6 drops to the suprapubic, sacral, and flank areas nightly for 4 weeks reduces the mean frequency of urination at 4 weeks and 8 weeks of follow-up, when compared with baseline. Complete resolution occurred in 24 patients receiving coconut oil, and 17 receiving the paraffin oil control. There was no improvement in 5 on coconut oil, and 14 on paraffin oil (110405). However, the validity of these findings is unclear since blinding was compromised by the different oil odors.
• Obesity. Although some clinical studies suggest that oral coconut oil may modestly reduce body weight or body mass index (BMI), most research is mixed. Details: A meta-analysis of clinical research shows that taking coconut oil in the diet or as a supplement daily decreases body weight, BMI, and fat mass percent by 0.75 kg, 0.28 kg/m², and 0.35%, respectively, when compared to other oils and fats, usually polyunsaturated oils. However, there was no effect on waist circumference or total fat mass, and significant changes did not occur in more than half of the individual studies (107665). These individual studies were generally small, of low to moderate quality, and utilized a wide range of dosing regimens. Doses of coconut oil used in the individual studies ranged from 7-93 mL or 14% to 15% of daily energy intake and included extra-virgin, virgin, bleached and deodorized, hydrogenated, and ordinary sources. Study durations ranged from 4 weeks to 2 years (17938,17942,99102,107665). Virgin coconut oil is associated with reduced hunger and desire to eat in normal weight subjects, but not in obese subjects, when compared with extra virgin olive oil. It is also associated with reduced energy intake at the next meal when compared with olive oil in obese subjects, but not in normal weight subjects (110406).
• Psoriasis. It is unclear if topical coconut oil is beneficial in patients with psoriasis. Details: One small clinical study in patients with psoriasis shows that applying coconut oil to the skin before treatment with ultraviolet B (UVB) or psoralen and ultraviolet A (PUVA) phototherapy does not seem to improve the clearance of psoriasis (12356). More evidence is needed to rate coconut oil for these uses.

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INSUFFICIENT RELIABLE EVIDENCE to RATE

• Atopic dermatitis (eczema). It is unclear if oral hemp seed oil is beneficial in patients with eczema. Details: A small preliminary clinical trial in patients with eczema shows that taking hemp seed oil 30 mL daily for 8 weeks improves skin dryness, itchiness, and use of dermal medication when compared with baseline, but not when compared with an olive oil control (101125).
• Constipation. Oral hemp seed has only been evaluated in combination with other ingredients; its effect when used alone is unclear. Details: Clinical research in patients with functional constipation shows that taking a proprietary Chinese herbal medicine (Hemp Seed Pill) containing hemp seed, rhubarb root, peony root, apricot kernel, bitter orange fruit, and magnolia bark twice daily for 8 weeks results in a response rate to 43%, compared with 8% in those taking placebo. The response rate was defined as an increase of at least 1 complete spontaneous bowel movement per week. This combination product also improved the responder rate in the 2 weeks after treatment, as well as the overall use of rescue therapy, when compared with placebo (101127). Data from this study pooled with data from another larger study in adults with functional constipation shows that this same product increases the likelihood of complete response, defined as at least 3 complete spontaneous bowel movements per week or an increase over baseline of at least 1 weekly, by 1.43 times when compared with placebo. Complete spontaneous bowel movements per week also increased by 1 when compared with placebo (107319). It is unclear if these effects are due to hemp seed, other ingredients, or the combination.
• Dysmenorrhea. Although there is interest in using oral hemp for dysmenorrhea, there is insufficient reliable information about the clinical effects of oral hemp for this condition.
• Familial hypercholesterolemia. It is unclear if oral hemp seed oil is beneficial in children with this condition. Details: A small preliminary clinical trial shows that taking hemp seed oil (AlfaLife, Freia Farmaceutici Srl) 3 grams daily for 8 weeks does not improve levels of total or low-density lipoprotein (LDL) cholesterol when compared with no treatment in hyperlipidemic children aged 6-16 years who are also following a low-fat diet with high fruit and vegetable intake (101144).
• Joint pain. Although there is interest in using oral hemp for joint pain, there is insufficient reliable information about the clinical effects of oral hemp for this condition.
• Multiple sclerosis (MS). Oral hemp seed has only been evaluated in combination with other ingredients; its effect when used alone is unclear. Details: A small clinical study in patients with relapsing-remitting MS shows that taking a combination of hemp seed oil 5.4-6.3 grams and evening primrose oil three times daily for 6 months seems to improve disability scores and relapse rate when compared to baseline. However, the control group in this study ingested olive oil and also experienced notable improvements in disability and relapse rates (88183). This study is limited due to high dropout rate and because there was no statistical comparison between treatment and control groups.
• Obesity. It is unclear if an oral cannabidiol-rich hemp oil extract helps to improve weight loss. Details: A small clinical study in healthy overweight adults shows that taking a specific hemp oil extract (PlusCBD Extra Strength Hemp Extract, CV Sciences) as 60 mg, providing 15 mg cannabidiol, daily for 6 weeks, does not reduce weight or body mass index when compared with placebo (103805). The validity of this study is limited due to its exploratory nature and lack of control for voluntary dietary changes.
• Osteoarthritis. It is unclear if oral hemp seed is beneficial in patients with osteoarthritis. Details: A clinical study in 18 older adults with osteoarthritis undergoing in-hospital rehabilitation following knee or hip arthroplasty shows that consuming pasta enriched with hemp seed flour for 6 weeks improves pain scores by about 3 points, compared with only 1 point in those consuming a regular pasta control (107320).
• Psychological well-being. Although there is interest in using oral hemp for psychological well-being, there is insufficient reliable information about the clinical effects of oral hemp for this condition. More evidence is needed to rate hemp for these uses.

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LIKELY SAFE ...when used orally in food amounts. Coconut oil can be safely consumed as a component of the diet (12361,17935,94452,106494). However, coconut oil should not be considered a healthy alternative to other saturated fats (94453,94643). Coconut oil contains more saturated fat than animal based fats, including lard and butter (94643). Therefore, like all saturated fats, coconut oil should be used in moderation (94453,94643). ...when used topically and appropriately. Commercial products containing coconut oil in concentrations up to 100% have been used with apparent safety. However, most research has used commercial products with concentrations up to 70% (12356,17936,17941).

POSSIBLY SAFE ...when used orally and appropriately in medicinal amounts, short-term. Taking coconut oil up to 10 mL orally two or three times daily for up to 12 weeks has been used with apparent safety in clinical research (17938,17942,90615,106493).

CHILDREN: POSSIBLY SAFE
when used topically and appropriately, short-term. Coconut oil has been used with apparent safety in children and neonates for about one month (13483,17937,90614,90616,96204,101873). There is insufficient reliable information available about the safety of coconut oil when taken orally in children.

PREGNANCY AND LACTATION:
There is insufficient reliable information available about the safety of using coconut oil in medicinal amounts during pregnancy or lactation. Coconut oil ingestion increases the amount of lauric acid in breast milk within 10 hours. This indicates that fatty acids from coconut oil are rapidly transferred into human breast milk following oral intake (14086). The impact of this increase in lauric acid on nursing infants is not known.

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LIKELY SAFE ...when hemp seed, hemp protein, and hemp seed oil are used orally in food amounts. Hulled hemp seed, hemp seed protein powder, and hemp seed oil are generally recognized as safe (GRAS) in the US (100531).

POSSIBLY SAFE ...when hemp seed oil is used orally and appropriately as medicine, short-term. Hemp seed oil in doses of 2-6.3 grams daily has been safely used for 3-6 months (88183,16791,101145). Hemp seed oil in doses of 30 mL (27.6 grams) daily has been used safely for 2 months (101125). There is insufficient reliable evidence available about the safety of hemp oil, flowers, or leaves.

CHILDREN:
There is insufficient reliable information available about the safety of hemp in children. Adverse effects have been noted in case reports, but details related to specific hemp products are limited (101153,110287).

PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.

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ACE INHIBITORS (ACEIs) Interaction Rating = Minor Be watchful with this combination. Severity = Moderate •  Occurrence = Unlikely •  Level of Evidence = D Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.  Details Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model (101136). However, hempseed oil consumption does not seem to reduce blood pressure in humans (101144). Until more is known, monitor blood pressure and potassium levels.

ANTICOAGULANT/ANTIPLATELET DRUGS Interaction Rating = Minor Be watchful with this combination. Severity = Mild •  Occurrence = Possible •  Level of Evidence = D Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.  Details In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro (101137). However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro (16791).

ANTIHYPERTENSIVE DRUGS Interaction Rating = Minor Be watchful with this combination. Severity = Moderate •  Occurrence = Unlikely •  Level of Evidence = D Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.  Details In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals (101136). Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans (101144).

ESTROGENS Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.  Details In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol (101132). The mechanism of action for this effect is unclear.

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General ...Orally and topically, coconut oil is generally well tolerated.
Most Common Adverse Effects:
Orally: Increased cholesterol levels.
Serious Adverse Effects (Rare):
All routes of administration: Allergic reactions, including anaphylaxis, in sensitive individuals.

Cardiovascular ...Due to its high saturated fat content, there has been some speculation that consuming coconut oil might increase cholesterol levels and the risk of cardiovascular disease. Several population and clinical studies have found that consuming coconut oil increases total cholesterol, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol in some patients (12361,14407,17935,17940,94451,94452,99103,101877,101879,106489,106494). In patients with normal to high cholesterol levels, consuming a daily diet providing 30% to 36% of calories from fat, of which 46% to 66% is from coconut oil, for 4-12 weeks increases total cholesterol by about 12-15 mg/dL, low-density lipoprotein (LDL) cholesterol by about 9-12 mg/dL, and HDL cholesterol by 3-6 mg/dL when compared to a diet containing vegetable oils, especially those rich in polyunsaturated fatty acids (17935,94451,94452,101877,106489). In some cases, these cholesterol effects are similar to those seen in patients consuming a similar diet containing butter or beef fat (12361,17935,94451,99103,101879). Despite the potential effects of coconut oil on cholesterol levels, population research has not found an association with coconut oil consumption and risk of adverse cardiovascular events such as myocardial infarction or angina (14407,96205). Advise patients not to rely on coconut oil as a "healthy" alternative to other saturated fats.

Dermatologic ...In one case report, a 6-year-old child developed urticaria and hives from applying coconut oil to the skin. The child had been exposed to coconut oil consistently since 2 weeks of age, indicating sensitization over the course of regular exposure (95806). In clinical research, one patient reported localized pruritus immediately after applying a combination of coconut oil, anise oil, and ylang ylang (13483). It is unclear if this event was due to coconut oil, other ingredients, or the combination. Also, it is possible that this was an idiosyncratic event.

Gastrointestinal ...Orally, diarrhea and gastroenteritis have been reported rarely (101877).

Hepatic ...Orally, taking virgin coconut oil in the diet for 28 days modestly increased levels of liver enzymes in patients with coronavirus disease 2019 (COVID-19). However, it is unclear if this was due to the coconut oil or to the illness (107664).

Immunologic ...Several cases of allergic reactions have been reported for patients who consumed coconut fruit. In some of the cases, the patients were previously diagnosed with sensitivity to other tree nuts, including peanuts, so cross-sensitivity is suspected. In a separate case report, a 17-year-old male was found to be sensitized to both coconut and buckwheat, indicating a possible cross-sensitivity between the two allergens (95808). In other cases, the patients did not show sensitivity to any other allergens, so the patients were considered to have a single allergy to coconut fruit (12359,12360).
Because coconut oil is derived from coconut fruit, ingestion of coconut oil may theoretically cause allergic reactions in patients with confirmed allergy to coconut fruit. In one case report, a 6-year-old child who had previously experienced urticaria and hives from applying coconut oil to the skin experienced throat swelling and anaphylaxis after eating food containing coconut, indicating a sensitivity to both the fruit and the oil via both topical application and ingestion (95806). However, allergic reactions to coconut appear to occur significantly less often than allergies to other food items such as wheat, milk, soy, or peanut (14408).

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General ...Orally, hemp products are generally well tolerated in food amounts. In larger amounts, hemp seed oil seems to be well tolerated.
Serious Adverse Effects (Rare):
Orally: Rare cases of anaphylaxis have been reported. Long QT syndrome, torsades de pointes, and syncope have also been reported rarely.

Cardiovascular ...Acquired long QT syndrome, torsades de pointes, and syncope have been reported in a 56-year-old woman following the intake of supplements containing hemp oil. The hemp supplements provided cannabidiol (CBD), and possibly cannabigerol (CBG). Although the exact dose is unknown, up to six times the recommended dose had been used for approximately 6 weeks, in combination with a supplement containing berberine. While hospitalized, intravenous magnesium and saline were used to stabilize heart rhythm. It is unknown whether this adverse effect was related to the hemp oil, berberine, or their interaction (110104).

Hepatic ...Orally, there is a case report of elevated liver enzymes and hepatitis in a two-year-old boy given hemp extract 2. 5 mL, providing 125 mg phytocannabinoid, five to eight times daily for infantile spasms and refractory seizures. The total dose of phytocannabinoids was approximately 60-100 mg/kg daily (110287).

Immunologic ...Orally, there are case reports of allergy to hemp seed, although this is uncommon (101140,101154). A 44-year-old male developed hives during a meal of hemp seed-crusted seafoods. Later, he developed facial swelling, shortness of breath, and problems speaking. Evaluation revealed allergy to a specific protein in hemp seed. He did not react to smoked cannabis (101140). In other cases, anaphylaxis, facial swelling, and worsening asthma have been reported in association with a first exposure to hemp seed, although some had smoked cannabis previously (101154).
Topically, a case of patch-test confirmed allergic contact dermatitis to hemp seed oil has been reported in a 22-year-old woman. The initial rash started at the application point on her back and spread to her arms, hands, and neck (110288).
Airborne exposure to hemp pollen is a relatively common cause of allergic respiratory symptoms in some locations (101155).

Neurologic/CNS ...Orally, cases of acute cannabinoid toxicity with neurological symptoms in children and adults have been associated with intake of hemp seed oil. There is a case report of decreased alertness, stupor, bloodshot eyes, and fixed gaze in a 2-year-old male probably related to the intake of one teaspoon hemp seed oil (CANAH) containing 0.06% delta-9-tetrahydrocannabinol (THC) twice daily for 3 weeks. After stopping the oil, irritability was reported over the next few days (101153).

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