100% Pure Black Raspberry [Discontinued] by Genesis Today

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Hypertension. Preliminary clinical research shows that taking black raspberry extract 1500 mg or 2500 mg orally daily for 8 weeks reduces 24-hour systolic blood pressure by 1-7 mmHg and nighttime systolic blood pressure by 2-5 mmHg compared to baseline in patients with prehypertension. Compared to the placebo group, these changes were significant. However, taking black raspberry extract does not significantly improve 24-hour diastolic blood pressure, daytime systolic or diastolic blood pressure, nighttime diastolic blood pressure, arterial stiffness, or abdominal visceral fat (96303). The effects of black raspberry on blood pressure in patients with established hypertension has not been studied.
• Impaired glucose tolerance (prediabetes). Preliminary clinical research in patients with prediabetes shows that taking black raspberry extract 900 mg or 1800 mg orally daily for 12 weeks decreases glucose area under the curve (AUC) after a 75-gram oral glucose tolerance test compared to placebo. However, taking black raspberry extract does not significantly improve hemoglobin A1c (HbA1c), fasting plasma glucose, insulin AUC, insulin resistance, or the proportion of patients converting to euglycemia (96302).
• Metabolic syndrome. Preliminary clinical research shows that, in addition to following the dietary approaches to stop hypertension (DASH) diet, taking black raspberry extract 750 mg orally daily for 12 weeks does not affect blood pressure, but does decrease the radial artery augmentation index, a measure of arterial stiffness, compared to placebo in individuals with metabolic syndrome (96343).
• Oral cancer. Preliminary clinical research shows that applying a 10% black raspberry bioadhesive gel 0.5 grams four times daily for 3 months decreases oral intraepithelial neoplasia (OIN) size by approximately 26%, decreases histopathologic grade, and reduces loss of heterozygosity events, compared to placebo in patients with premalignant oral epithelial lesions (96304). However, 70% of patients enrolled in the trial had a history of lesion recurrence, and 3 months posttreatment, 6 out of 22 patients in the treatment group and 7 out of 17 in the placebo group had recurrence of the lesion at the former treatment site. More evidence is needed to rate black raspberry for these uses.

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LIKELY SAFE ...when used orally in amounts commonly found in foods (13530).

POSSIBLY SAFE ...when used orally and appropriately in medicinal amounts, short-term. In clinical research, black raspberry fruit extract has been used safely in doses up to 1800 mg daily for up to 12 weeks (96302,96343). Higher doses of black raspberry fruit extract (2500 mg daily) has also been used safely for up to 8 weeks (96303).

POSSIBLY SAFE ...when used topically and appropriately, short-term. In a small clinical trial, a black raspberry bioadhesive gel was used safely in doses of 0.5 grams applied four times daily in the mouth for 3 months (96304).

PREGNANCY AND LACTATION: LIKELY SAFE
when used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of black raspberry in medicinal amounts during pregnancy or breast-feeding; avoid using.

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General ...Orally and topically, black raspberry seems to be well tolerated (96302,96303,96304,96343). No adverse effects have been reported; however, most studies have not conducted a thorough evaluation of safety outcomes.

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