Chrysin 500 [Discontinued] by MRM

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Anxiety. Although there has been interest in using oral chrysin for anxiety, there is insufficient reliable information about the clinical effects of chrysin for this purpose.
• Athletic performance. Although there has been interest in using oral chrysin for improving athletic performance, there is insufficient reliable information about the clinical effects of chrysin for this purpose.
• Cancer. Although there has been interest in using oral chrysin for preventing cancer, there is insufficient reliable information about the clinical effects of chrysin for this purpose.
• Gout. Although there has been interest in using oral chrysin for gout, there is insufficient reliable information about the clinical effects of chrysin for this purpose.
• HIV/AIDS. Although there has been interest in using oral chrysin for HIV/AIDS, there is insufficient reliable information about the clinical effects of chrysin for this purpose.
• Male infertility. Although there has been interest in using oral chrysin for male infertility, there is insufficient reliable information about the clinical effects of chrysin for this purpose.
• Muscle strength. Oral chrysin has only been evaluated in combination with other ingredients; its effect when used alone is unclear. Details: A small clinical trial in young male athletes undergoing resistance training shows that taking a combination of chrysin 625 mg with androstenedione, dehydroepiandrosterone (DHEA), tribulus, indole-3-carbinole, and saw palmetto daily for 8 weeks does not increase muscle strength, improve body composition, or increase testosterone levels when compared with placebo (7514). More evidence is needed to rate chrysin for these uses.

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There is insufficient reliable information available about the safety of chrysin.

PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.

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ANTICOAGULANT/ANTIPLATELET DRUGS Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, chrysin might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.  Details In vitro evidence suggests that chrysin might inhibit platelet aggregation (7502,42914,42920,42952,93640).

AROMATASE INHIBITORS Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, chrysin might increase the effects and adverse effects of aromatase inhibitors.  Details In vitro research suggests that chrysin might decrease estrogen synthesis by acting as an aromatase (estrogen synthetase) inhibitor. (7507,7508).

CONTRACEPTIVE DRUGS Interaction Rating = Moderate Be cautious with this combination. Severity = High •  Occurrence = Possible •  Level of Evidence = D Theoretically, chrysin might reduce the efficacy of estrogen-containing contraceptive drugs.  Details In vitro research suggests that chrysin might have antiestrogenic activity (42905,42960,42962).

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES Interaction Rating = Minor Be watchful with this combination. Severity = Moderate •  Occurrence = Unlikely •  Level of Evidence = D Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.  Details In vitro research suggests that chrysin inhibits CYP1A2 isozymes (7503,8172,42936,42956). However, chrysin does not appear to inhibit CYP1A2-dependent caffeine metabolism in animals (93643). Due to chrysin's low bioavailability and rapid metabolism to glucuronide and sulfate conjugates, this interaction is unlikely (7502,7504,7505,8168,42931,42938,93643).

DICLOFENAC (Voltaren, others) Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, chrysin might increase the effects and adverse effects of diclofenac.  Details In vitro research suggests that chrysin and its sulfate conjugate inhibit diclofenac metabolism (106436). It is speculated that chrysin and its sulfate conjugate reduce the metabolism of diclofenac by inhibiting cytochrome P450 2C9 (106436). This effect has not been reported in humans.

ESTROGENS Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, chrysin might decrease the effects of estrogen therapy.  Details In vitro research suggests that chrysin might have antiestrogenic activity (42905,42960,42962).

GLUCURONIDATED DRUGS Interaction Rating = Minor Be watchful with this combination. Severity = Moderate •  Occurrence = Unlikely •  Level of Evidence = D Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.  Details In vitro research suggests that chrysin might induce UDP-glucuronosyltransferase 1A1 (UGT1A1) (7504,7513,8170).

MEPHENYTOIN (Mesantoin) Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, chrysin might increase the effects and adverse effects of mephenytoin.  Details In vitro research suggests that chrysin and its sulfate and glucuronide conjugates inhibit S-mephenytoin metabolism. It is speculated that chrysin and its conjugates reduce the metabolism of S-mephenytoin by inhibiting cytochrome P450 2C19 (106436). This effect has not been reported in humans.

TESTOSTERONE Interaction Rating = Minor Be watchful with this combination. Severity = Mild •  Occurrence = Possible •  Level of Evidence = D Theoretically, chrysin might increase the effects and adverse effects of testosterone.  Details In vitro research suggests that chrysin and its sulfate conjugate inhibit testosterone metabolism. It is speculated that chrysin and its sulfate conjugate reduce the metabolism of testosterone by inhibiting cytochrome P450 3A4 (106436). This effect has not been reported in humans.

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General ...No adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted.

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