D-Aspartic Acid 3000 mg [Discontinued] by Nutricost

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Athletic performance. Although there has been interest in using oral aspartic acid for athletic performance, there is insufficient reliable information about the clinical effects of aspartic acid for this purpose.
• Fatigue. Although there has been interest in using oral aspartic acid for fatigue, there is insufficient reliable information about the clinical effects of aspartic acid for this purpose.
• Muscle strength. It is unclear if oral aspartic acid is beneficial for muscle strength. Details: Preliminary clinical research shows that taking D-aspartic acid 3-6 grams orally daily for 1-3 months does not improve muscle strength when compared with placebo in resistance-trained males (94497,97576). The effect of D-aspartic acid in untrained males, or in any females, is not clear.
• Opioid withdrawal. Although there has been interest in using oral aspartic acid for opioid withdrawal, there is insufficient reliable information about the clinical effects of aspartic acid for this purpose. More evidence is needed to rate aspartic acid for these uses.

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LIKELY SAFE ...when used orally in amounts found in foods (94500).

POSSIBLY SAFE ...when aspartic acid is used orally and appropriately, short-term. D-aspartic acid 3-6 grams daily has been used with apparent safety in clinical trials for up to 3 months (94497,97576). L-aspartic acid has been used in doses up to 8 grams daily, short-term, without reports of adverse effects (94500).

CHILDREN: POSSIBLY UNSAFE
when aspartic acid is used orally in infants. In rodents, aspartic acid given orally within a few days of birth caused neuronal necrosis in the hypothalamus. This adverse effect was not seen in nonhuman newborn primates and has not been assessed in humans. Until more data is available, the Institute of Medicine (IOM) and the Food and Nutrition Board advise that aspartic acid be avoided in infants (94500). There is insufficient reliable information available about the use of aspartic acid supplements in children and adolescents; avoid using in amounts exceeding those found in food.

PREGNANCY AND LACTATION: LIKELY SAFE
when used orally in amounts found in foods (94500).

PREGNANCY AND LACTATION: POSSIBLY UNSAFE
when aspartic acid is used orally. In rodents, aspartic acid given orally within a few days of birth caused neuronal necrosis in the hypothalamus. This adverse effect was not seen in nonhuman newborn primates and has not been assessed in humans. Until more data is available, the Institute of Medicine (IOM) and the Food and Nutrition Board advise that pregnant or breast-feeding women avoid the use of aspartic acid (94500).

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General ...No adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted.

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