Each tablet contains: Solidago virgaurea 4X • Ammi visnaga 6X • Berberis vulgaris 6X • Citricum Acidum 6X • Pareira Brava 6X • Cantharis 8X • Hepar Sulphuris Calcareum 8X • Nitricum Acidum 8X • Mercurius Solubilis 10X • Arsenicum Album 30X.
Brand name products often contain multiple ingredients. To read detailed information about each ingredient, click on the link for the individual ingredient shown above.
This is a homeopathic preparation. Homeopathy is a system of medicine established in the 19th century by a German physician named Samuel Hahnemann. Its basic principles are that "like treats like" and "potentiation through dilution." For example, in homeopathy, diarrhea would be treated with an extreme dilution of a substance that normally causes diarrhea when taken in high doses.
Practitioners of homeopathy believe that more dilute preparations are more potent. Many homeopathic preparations are so diluted that they contain little or no active ingredient. Therefore, most homeopathic products are not expected to have any pharmacological effects, drug interactions, or other harmful effects. Any beneficial effects are controversial and cannot be explained by current scientific methods.
Dilutions of 1 to 10 are designated by an "X." So a 1X dilution = 1:10, 3X=1:1000; 6X=1:1,000,000. Dilutions of 1 to 100 are designated by a "C." So a 1C dilution = 1:100; 3C = 1:1,000,000. Dilutions of 24X or 12C or more contain zero molecules of the original active ingredient.
Homeopathic products are permitted for sale in the US due to legislation passed in 1938 sponsored by a homeopathic physician who was also a Senator. The law still requires that the FDA allow the sale of products listed in the Homeopathic Pharmacopeia of the United States. However, homeopathic preparations are not held to the same safety and effectiveness standards as conventional medicines. For more information, see the Homeopathy monograph.
Below is general information about the effectiveness of the known ingredients contained in the product BHI Uri-Cleanse. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product BHI Uri-Cleanse. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when the fruit is consumed orally in food amounts (13527). There is insufficient reliable information available about the safety of European barberry when used orally in medicinal amounts or when used topically.
CHILDREN: LIKELY UNSAFE
when used orally in newborns.
The berberine constituent of European barberry can cause kernicterus in newborns, particularly preterm neonates with hyperbilirubinemia (2589). There is insufficient reliable information available about the safety of European barberry when used orally in older children.
PREGNANCY: LIKELY UNSAFE
when used orally.
Berberine is thought to cross the placenta and may cause harm to the fetus. Kernicterus has developed in newborn infants exposed to berberine (2589).
LACTATION: LIKELY UNSAFE
when used orally.
Berberine and other harmful constituents can be transferred to the infant through breast milk (2589).
POSSIBLY SAFE ...when used topically as a toothpaste, short-term. A specific toothpaste (Bucovia, Givaudan) containing goldenrod extract 0.3% and sodium fluoride 0.15% has been used safely twice daily for up to 4 weeks (105115). There is insufficient reliable information available about the safety of goldenrod when used orally or when applied topically to the skin.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY UNSAFE ...when used orally in high doses or for an extended duration. High doses of khella or use over an extended period of time can cause increases in liver enzymes and possible liver damage (2). There is insufficient reliable information available about the safety of khella when applied topically.
PREGNANCY: LIKELY UNSAFE
when used orally.
The active constituent, khellin, has uterine stimulant activity (19); contraindicated.
LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product BHI Uri-Cleanse. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, taking European barberry with anticholinergic drugs might cause additive effects.
 Details
In vitro evidence suggests that European barberry might have anticholinergic properties (13527).
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Theoretically, European barberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
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Theoretically, taking European barberry with antidiabetes drugs might increase the risk of hypoglycemia.
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Preliminary clinical evidence suggests that European barberry juice reduces fasting glucose levels in patients with type 2 diabetes who are also taking antidiabetes drugs (98575). Additionally, some animal studies show that berberine, a constituent of European barberry, has antiglycemic potential (33622,33667). Monitor blood glucose levels closely.
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Theoretically, taking European barberry with antihypertensive drugs might increase the risk of hypotension.
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Theoretically, taking European barberry with cholinergic drugs might decrease the effects of cholinergic drugs.
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In vitro evidence suggests that European barberry might have anticholinergic properties (13527).
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Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
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Theoretically, concomitant use with cyclosporine may cause additive effects.
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Berberine, a constituent of European barberry, can reduce the metabolism and increase serum levels of cyclosporine. This effect is attributed to the ability of berberine to inhibit cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine (13524). Theoretically, European barberry might have a similar effect.
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Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Details
There is very preliminary evidence suggesting that berberine, a constituent of European barberry, might inhibit the CYP3A4 enzyme (13524). Theoretically, European barberry might have a similar effect.
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Theoretically, goldenrod might increase the effects and adverse effects of diuretic drugs.
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Theoretically, khella might decrease the effectiveness of cardiac glycosides like digoxin. The khella constituent visnadin has negative inotropic effects that might counter the effects of cardiac glycosides (19,869).
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Theoretically, khella might have additive adverse effects on the liver when used with hepatotoxic drugs. Khella can increase liver transaminases (2,2522). Some drugs that can adversely affect the liver include acetaminophen (Tylenol), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), and many others.
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Theoretically, concomitant use might result in increased photosensitivity. Khella constituents can cause photosensitivity (2521,7162). Some drugs that cause photosensitivity include amitriptyline (Elavil), quinolones (Ciprofloxacin, others), sulfa drugs (Septra, Bactrim, others), and tetracycline.
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Below is general information about the adverse effects of the known ingredients contained in the product BHI Uri-Cleanse. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General ...European barberry is generally well tolerated when consumed in amounts commonly found in food. A thorough evaluation of safety outcomes has not been conducted for the use of larger, medicinal amounts. Topically, European barberry seems to be well tolerated.
Hepatic ...Orally, a case of hepatitis-associated aplastic anemia is reported in an adult male after consuming European barberry 15 drops and nannari root 15 drops twice a day for 2 weeks. The patient presented with lethargy, loss of appetite, and jaundice that progressed to high-grade fevers, chills, rigors, severe pancytopenia, and abnormal liver function tests. Liver biopsy was suggestive of drug-induced liver injury. The patient was hospitalized for multiple infections and symptomatic thrombocytopenia. Despite receiving supportive care, blood transfusions, and corticosteroids, the patient died 7 weeks after diagnosis (110021). The exact reason for this adverse effect is not clear.
General
...There is a limited amount of information available about the adverse effects of goldenrod.
Most Common Adverse Effects:
Topically: Allergic contact dermatitis in sensitive individuals.
Dermatologic ...Topically, goldenrod has been reported to cause allergic contact dermatitis (52558,52581).
Immunologic ...Topically, goldenrod has been reported to cause allergic contact dermatitis (52558,52581). Environmental exposure to goldenrod has been reported to cause an allergic reaction involving rhinoconjunctivitis and bronchial asthma in one case report (52558).
Pulmonary/Respiratory ...Environmental exposure to goldenrod has been reported to cause a delayed allergic reaction involving rhinoconjunctivitis and bronchial asthma in one case report of a 42 year-old woman who worked at a flower shop and was exposed to members of the Asteraceae/Compositae family, including goldenrod (52558).
General ...Orally, prolonged use or use of high doses of khella can cause nausea, dizziness, constipation, lack of appetite, headache, itching, and insomnia. In some patients, khella can cause elevated liver transaminase and gamma-glutamyltransferase (GGT) levels (2). There is also some concern that khella might cause photosensitivity (2,7162).
Dermatologic ...Orally, prolonged use or use of high doses of khella can cause itching (2). There is also some concern that khella might cause photosensitivity because of the constituents khellin and furocoumarin (2,7162).
Gastrointestinal ...Orally, prolonged use or use of high doses of khella can cause nausea, constipation, and lack of appetite (2).
Hepatic ...Orally, in some patients, prolonged use or use of high doses of khella can cause elevated liver transaminase and gamma-glutamyltransferase (GGT) levels (2), probably due to its khellin constituent, which is known to affect liver enzymes (6,2522).
Neurologic/CNS ...Orally, prolonged use or use of high doses of khella can cause dizziness, headache, and insomnia (2).
