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Lai, M. Y., Hsiu, S. L., Chen, C. C., Hou, Y. C., and Chao, P. D. Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. Biol Pharm Bull 2003;26(1):79-83. View abstract.
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Bochorakova, H., Paulova, H., Slanina, J., Musil, P., and Taborska, E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Phytother.Res 2003;17(6):640-644. View abstract.
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Liu, J. J., Huang, T. S., Cheng, W. F., and Lu, F. J. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. Int J Cancer 9-10-2003;106(4):559-565. View abstract.
33358
Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Cancer Res 7-15-2003;63(14):4037-4043. View abstract.
33363
Regulska-Ilow, B., Biernat, J., Grajeta, H., Ilow, R., and Drzewicka, M. Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. Nahrung 2004;48(2):123-128. View abstract.
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Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., and Zhang, D. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. Cancer Lett. 7-28-2004;211(1):39-46. View abstract.
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Ciesielska, E., Wolszczak, M., Gulanowski, B., Szulawska, A., Kochman, A., and Metodiewa, D. In vitro antileukemic, antioxidant and prooxidant activities of Antoksyd S (C/E/XXI): a comparison with baicalin and baicalein. In Vivo 2004;18(4):497-503. View abstract.
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Wang, J., Yu, Y., Hashimoto, F., Sakata, Y., Fujii, M., and Hou, D. X. Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells. Int J Mol Med 2004;14(4):627-632. View abstract.
33369
Kaplya, O. A., Sherstoboev, E. Y., Zueva, E. P., Razina, T. G., Amosova, E. N., and Krylova, S. G. Effect of baikal skullcap extract administered alone or in combination with cyclophosphamide on natural cytotoxicity system in mice with Lewis lung carcinoma. Bull Exp Biol Med 2004;137(5):471-474. View abstract.
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Lee, Y., Yeo, H., Liu, S. H., Jiang, Z., Savizky, R. M., Austin, D. J., and Cheng, Y. C. Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring. J Med Chem 10-21-2004;47(22):5555-5566. View abstract.
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Huang, Y., Tsang, S. Y., Yao, X., and Chen, Z. Y. Biological properties of baicalein in cardiovascular system. Curr Drug Targets.Cardiovasc.Haematol.Disord 2005;5(2):177-184. View abstract.
33375
Bonham, M., Posakony, J., Coleman, I., Montgomery, B., Simon, J., and Nelson, P. S. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clin Cancer Res 5-15-2005;11(10):3905-3914. View abstract.
33378
Chen, C. S., Chen, N. J., Lin, L. W., Hsieh, C. C., Chen, G. W., and Hsieh, M. T. Effects of Scutellariae Radix on gene expression in HEK 293 cells using cDNA microarray. J Ethnopharmacol. 5-24-2006;105(3):346-351. View abstract.
33380
Himeji, M., Ohtsuki, T., Fukazawa, H., Tanaka, M., Yazaki, S., Ui, S., Nishio, K., Yamamoto, H., Tasaka, K., and Mimura, A. Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. Cancer Lett. 1-8-2007;245(1-2):269-274. View abstract.
33381
Shieh, D. E., Cheng, H. Y., Yen, M. H., Chiang, L. C., and Lin, C. C. Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines. Am J Chin Med 2006;34(2):245-261. View abstract.
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Scheck, A. C., Perry, K., Hank, N. C., and Clark, W. D. Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells. BMC.Complement Altern Med 2006;6:27. View abstract.
33389
Kumagai, T., Muller, C. I., Desmond, J. C., Imai, Y., Heber, D., and Koeffler, H. P. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Leuk.Res 2007;31(4):523-530. View abstract.
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Leung, H. W., Yang, W. H., Lai, M. Y., Lin, C. J., and Lee, H. Z. Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. Food Chem Toxicol. 2007;45(3):403-411. View abstract.
33395
Lee, E., Enomoto, R., Suzuki, C., Ohno, M., Ohashi, T., Miyauchi, A., Tanimoto, E., Maeda, K., Hirano, H., Yokoi, T., and Sugahara, C. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. Ann N Y Acad Sci 2007;1095:521-526. View abstract.
33401
Baumann, S., Fas, S. C., Giaisi, M., Muller, W. W., Merling, A., Gulow, K., Edler, L., Krammer, P. H., and Li-Weber, M. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. Blood 2-15-2008;111(4):2354-2363. View abstract.
33408
Waisundara, V. Y., Hsu, A., Huang, D., and Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. Am J Chin Med 2008;36(3):517-540. View abstract.
33409
Tarrago, T., Kichik, N., Claasen, B., Prades, R., Teixido, M., and Giralt, E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Bioorg.Med Chem 8-1-2008;16(15):7516-7524. View abstract.
33410
You, C. L., Su, P. Q., and Zhou, X. X. [Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism]. Zhongguo Zhong.Yao Za Zhi 2008;33(9):1064-1066. View abstract.
33413
Shang, Y. Z., Qin, B. W., Cheng, J. J., and Miao, H. Effect of Scutellaria flavonoids on KCN-induced damages in rat pheochromocytoma PC12 cells. Indian J Med Res 2008;127(6):610-615. View abstract.
33414
Blach-Olszewska, Z., Jatczak, B., Rak, A., Lorenc, M., Gulanowski, B., Drobna, A., and Lamer-Zarawska, E. Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones. J Interferon Cytokine Res 2008;28(9):571-581. View abstract.
33417
Jianjun, J. and Huiru, D. Preparation of high-purity baicalein from Scutellaria baicalensis Georgi. Nat Prod Res 2008;22(16):1410-1412. View abstract.
33419
Li, H. N., Nie, F. F., Liu, W., Dai, Q. S., Lu, N., Qi, Q., Li, Z. Y., You, Q. D., and Guo, Q. L. Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. Toxicology 3-4-2009;257(1-2):80-85. View abstract.
33420
Shih, H. C., Hsu, C. S., and Yang, L. L. In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. J Biomed.Sci 2009;16:27. View abstract.
33423
Mu, X., He, G., Cheng, Y., Li, X., Xu, B., and Du, G. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Pharmacol Biochem Behav 2009;92(4):642-648. View abstract.
33426
Chen, Y., Lu, N., Ling, Y., Gao, Y., Wang, L., Sun, Y., Qi, Q., Feng, F., Liu, W., Liu, W., You, Q., and Guo, Q. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. Toxicology 5-2-2009;259(1-2):10-17. View abstract.
33428
Liu, W., Mu, R., Nie, F. F., Yang, Y., Wang, J., Dai, Q. S., Lu, N., Qi, Q., Rong, J. J., Hu, R., Wang, X. T., You, Q. D., and Guo, Q. L. MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells. Cancer Lett. 11-1-2009;284(2):198-207. View abstract.
33431
Huang, S. T., Wang, C. Y., Yang, R. C., Chu, C. J., Wu, H. T., and Pang, J. H. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. Phytomedicine. 2010;17(1):47-54. View abstract.
33432
Yoon, S. B., Lee, Y. J., Park, S. K., Kim, H. C., Bae, H., Kim, H. M., Ko, S. G., Choi, H. Y., Oh, M. S., and Park, W. Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. J Ethnopharmacol. 9-7-2009;125(2):286-290. View abstract.
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Hong, T., Jeong, M. L., Zahn, M., Fay, B. A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. J AOAC Int 2009;92(3):785-788. View abstract.
33439
Kim, E. H., Shim, B., Kang, S., Jeong, G., Lee, J. S., Yu, Y. B., and Chun, M. Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. J Ethnopharmacol. 11-12-2009;126(2):320-331. View abstract.
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Go, W. J., Ryu, J. H., Qiang, F., and Han, H. K. Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. J Nat Prod 2009;72(9):1616-1619. View abstract.
33442
Liu, S., Ma, Z., Cai, H., Li, Q., Rong, W., and Kawano, M. Inhibitory effect of baicalein on IL-6-mediated signaling cascades in human myeloma cells. Eur J Haematol. 2-1-2010;84(2):137-144. View abstract.
33443
Yang, X., Huang, S., Chen, J., Song, N., Wang, L., Zhang, Z., Deng, G., Zheng, H., Zhu, X. Q., and Lu, F. Evaluation of the adjuvant properties of Astragalus membranaceus and Scutellaria baicalensis GEORGI in the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models. Vaccine 1-8-2010;28(3):737-743. View abstract.
33444
Guo, H. X., Liu, D. H., Ma, Y., Liu, J. F., Wang, Y., Du, Z. Y., Wang, X., Shen, J. K., and Peng, H. L. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Acta Pharmacol Sin. 2009;30(11):1505-1512. View abstract.
33445
Kim, D. S., Son, E. J., Kim, M., Heo, Y. M., Nam, J. B., Ro, J. Y., and Woo, S. S. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. Planta Med 2010;76(7):678-682. View abstract.
33448
You, J., Gao, S., Jin, H., Li, W., Zhang, H., and Yu, A. On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi. J Chromatogr.A 3-19-2010;1217(12):1875-1881. View abstract.
33451
Xu, X. F., Cai, B. L., Guan, S. M., Li, Y., Wu, J. Z., Wang, Y., and Liu, B. Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. Invest New Drugs 2011;29(4):637-645. View abstract.
33455
Rosenbaum, C. C., O'Mathuna, D. P., Chavez, M., and Shields, K. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. Altern.Ther.Health Med. 2010;16(2):32-40. View abstract.
33456
Jiang, R. H., Su, W. C., Liu, H. F., Huang, H. S., and Chao, J. I. Opposite expression of securin and gamma-H2AX regulates baicalein-induced cancer cell death. J Cell Biochem 10-1-2010;111(2):274-283. View abstract.
33459
Lixuan, Z., Jingcheng, D., Wenqin, Y., Jianhua, H., Baojun, L., and Xiaotao, F. Baicalin attenuates inflammation by inhibiting NF-kappaB activation in cigarette smoke induced inflammatory models. Pulm.Pharmacol Ther 2010;23(5):411-419. View abstract.
33460
Linnebur, S. A., Rapacchietta, O. C., and Vejar, M. Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. Pharmacotherapy 2010;30(7):750, 258e-750, 262e. View abstract.
33462
Enomoto, R., Koshiba, C., Suzuki, C., and Lee, E. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. Cancer Chemother.Pharmacol 2011;67(5):1063-1072. View abstract.
33464
Hou, Y. C., Lin, S. P., Tsai, S. Y., Ko, M. H., Chang, Y. C., and Chao, P. D. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. Planta Med 2011;77(5):455-460. View abstract.
33470
Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. B., Blach-Olszewska, Z., and Aliev, G. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? CNS.Neurol.Disord Drug Targets. 2011;10(2):184-191. View abstract.
33473
Lin, A. M., Ping, Y. H., Chang, G. F., Wang, J. Y., Chiu, J. H., Kuo, C. D., and Chi, C. W. Neuroprotective effect of oral S/B remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) on iron-induced neurodegeneration in the nigrostriatal dopaminergic system of rat brain. J Ethnopharmacol. 4-12-2011;134(3):884-891. View abstract.
33477
Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., and Chang, F. C. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. J Ethnopharmacol. 5-17-2011;135(2):359-368. View abstract.
33479
Gao, J., Morgan, W. A., Sanchez-Medina, A., and Corcoran, O. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Toxicol.Appl.Pharmacol 8-1-2011;254(3):221-228. View abstract.
33484
Li, T., Li, N., Guo, Q., Ji, H., Zhao, D., Xie, S., Li, X., Qiu, Z., Han, D., Chen, X., and You, Q. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. Eur J Drug Metab Pharmacokinet. 6-29-2011; View abstract.
33487
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33488
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33492
Li, B. Q., Fu, T., Yan, Y. D., Baylor, N. W., Ruscetti, F. W., and Kung, H. F. Inhibition of HIV infection by baicalin--a flavonoid compound purified from Chinese herbal medicine. Cell Mol Biol Res 1993;39(2):119-124. View abstract.
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33502
Razina, T. G., Zueva, E. P., Litvinenko, V. I., and Kovalev, I. P. [A semisynthetic flavonoid from the Baikal skullcap (Scutellaria baicalensis) as an agent to enhance the efficacy of chemotherapy in experimental tumors]. Eksp.Klin Farmakol. 1998;61(2):54-56. View abstract.
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Wang R.T, Zhang J.X, and Dong Y.J. Protective effect of scutellaria baicalensis stem-leaf total flavonoid against hippocampus neurodamage induced by injection Aß25-35. Chinese Journal of Gerontology 2010;30(7):926-928.
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