Salgueiro JB, Ardenghi P, Dias M, et al. Anxiolytic natural and synthetic flavonoid ligands of the central benzodiazepine receptor have no effect on memory tasks in rats. Pharmacol Biochem Behav 1997;58:887-91. View abstract.

Williams CA, Harborne JB, Newman M, et al. Chrysin and other leaf exudate flavonoids in the genus Pelargonium. Phytochemistry 1997;46:1349-53. View abstract.

Galijatovic A, Otake Y, Walle UK, Walle T. Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. Xenobiotica 1999;29:1241-56. View abstract.

Lee H, Yeom H, Kim YG, et al. Structure-related inhibition of human hepatic caffeine N3-demethylation by naturally occurring flavonoids. Biochem Pharmacol 1998;55:1369-75. View abstract.

Galijatovic A, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells. Pharm Res 2000;17:21-6. View abstract.

Walle UK, Galijatovic A, Walle T. Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2. Biochem Pharmacol 1999;58:431-8. View abstract.

Kellis JT Jr, Vickery LE. Inhibition of human estrogen synthetase (aromatase) by flavones. Science 1984;225:1032-4. View abstract.

Kao YC, Zhou C, Sherman M, et al. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study. Environ Health Perspect 1998;106:85-92. View abstract.

Breinholt V, Lauridsen ST, Dragsted LO. Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat. Xenobiotica 1999;29:1227-40. View abstract.

Nagao A, Seki M, Kobayashi H. Inhibition of xanthine oxidase by flavonoids. Biosci Biotechnol Biochem 1999;63:1787-90. View abstract.

Steerenberg PA, Garssen J, Dortant P, et al. Protection of UV-induced suppression of skin contact hypersensitivity: a common feature of flavonoids after oral administration? Photochem Photobiol 1998;67:456-61. View abstract.

Critchfield JW, Coligan JE, Folks TM, Butera ST. Casein kinase II is a selective target of HIV-1 transcriptional inhibitors. Proc Natl Acad Sci U S A 1997;94:6110-5. View abstract.

Walle T, Otake Y, Galijatovic A, et al. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2. Drug Metab Dispos 2000;28:1077-82. View abstract.

Brown GA, Vukovich MD, Reifenrath TA, et al. Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men. Int J Sport Nutr Exerc Metab 2000;10:340-59. View abstract.

Brown GA, Vukovich MD, Martini ER, et al. Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. Int J Vitam Nutr Res 2001;71:293-301. View abstract.

Zanoli P, Avallone R, Baraldi M. Behavioral characterisation of the flavonoids apigenin and chrysin. Fitoterapia 2000;71:S117-S23. View abstract.

Wolfman C, Viola H, Paladini A, et al. Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea. Pharmacol Biochem Behav 1994;47:1-4.

Medina JH, Paladini AC, Wolfman C, et al. Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties. Biochem Pharmacol 1990;40:2227-31. View abstract.

Walle T, Otake Y, Brubaker JA, et al. Disposition and metabolism of the flavonoid chrysin in normal volunteers. Br J Clin Pharmacol 2001;51:143-6. View abstract.

Shin JS, Kim KS, Kim MB, et al. Synthesis and hypoglycemic effect of chrysin derivatives. Bioorg Med Chem Lett 1999;9:869-74. View abstract.

Galijatovic A, Otake Y, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation. Pharm Res 2001;18:374-9. View abstract.

Wang HK, Xia Y, Yang ZY, et al. Recent advances in the discovery and development of flavonoids and their analogues as antitumor and anti-HIV agents. Adv Exp Med Biol 1998;439:191-225. View abstract.

Lautraite S, Musonda AC, Doehmer J, et al. Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. Mutagenesis 2002;17:45-53. View abstract.

Wang, H. W., Lin, C. P., Chiu, J. H., Chow, K. C., Kuo, K. T., Lin, C. S., and Wang, L. S. Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin. Int J Cancer 5-1-2007;120(9):2019-2027. View abstract.

Yin, F., Giuliano, A. E., and Van Herle, A. J. Growth inhibitory effects of flavonoids in human thyroid cancer cell lines. Thyroid 1999;9(4):369-376. View abstract.

Comte, G., Daskiewicz, J. B., Bayet, C., Conseil, G., Viornery-Vanier, A., Dumontet, C., Di, Pietro A., and Barron, D. C-Isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance. J Med Chem 3-1-2001;44(5):763-768. View abstract.

Saarinen, N., Joshi, S. C., Ahotupa, M., Li, X., Ammala, J., Makela, S., and Santti, R. No evidence for the in vivo activity of aromatase-inhibiting flavonoids. J Steroid Biochem Mol.Biol 2001;78(3):231-239. View abstract.

Walle, U. K. and Walle, T. Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements. Drug Metab Dispos. 2002;30(5):564-569. View abstract.

Otake, Y., Hsieh, F., and Walle, T. Glucuronidation versus oxidation of the flavonoid galangin by human liver microsomes and hepatocytes. Drug Metab Dispos. 2002;30(5):576-581. View abstract.

Han, D. H., Denison, M. S., Tachibana, H., and Yamada, K. Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci.Biotechnol.Biochem 2002;66(7):1479-1487. View abstract.

Cipak, L., Rauko, P., Miadokova, E., Cipakova, I., and Novotny, L. Effects of flavonoids on cisplatin-induced apoptosis of HL-60 and L1210 leukemia cells. Leuk.Res 2003;27(1):65-72. View abstract.

Uhl, M., Ecker, S., Kassie, F., Lhoste, E., Chakraborty, A., Mohn, G., and Knasmuller, S. Effect of chrysin, a flavonoid compound, on the mutagenic activity of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and benzo(a)pyrene (B(a)P) in bacterial and human hepatoma (HepG2) cells. Arch.Toxicol. 2003;77(8):477-484. View abstract.

Wang, W., VanAlstyne, P. C., Irons, K. A., Chen, S., Stewart, J. W., and Birt, D. F. Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines. Nutr Cancer 2004;48(1):106-114. View abstract.

O'Leary, K. A., de Pascual-Tereasa, S., Needs, P. W., Bao, Y. P., O'Brien, N. M., and Williamson, G. Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutat.Res 7-13-2004;551(1-2):245-254. View abstract.

van Duursen, M. B., Sanderson, J. T., de Jong, P. C., Kraaij, M., and van den Berg, M. Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage. Toxicol Sci 2004;81(2):316-324. View abstract.

Zhang, S., Yang, X., and Morris, M. E. Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport. Pharm Res 2004;21(7):1263-1273. View abstract.

Sanderson, J. T., Hordijk, J., Denison, M. S., Springsteel, M. F., Nantz, M. H., and van den Berg, M. Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci 2004;82(1):70-79. View abstract.

Zhang, T., Chen, X., Qu, L., Wu, J., Cui, R., and Zhao, Y. Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells. Bioorg.Med Chem 12-1-2004;12(23):6097-6105. View abstract.

Woodman, O. L. and Chan, E. C. Vascular and anti-oxidant actions of flavonols and flavones. Clin Exp Pharmacol Physiol 2004;31(11):786-790. View abstract.

Monasterio, A., Urdaci, M. C., Pinchuk, I. V., Lopez-Moratalla, N., and Martinez-Irujo, J. J. Flavonoids induce apoptosis in human leukemia U937 cells through caspase- and caspase-calpain-dependent pathways. Nutr Cancer 2004;50(1):90-100. View abstract.

Zhang, S., Wang, X., Sagawa, K., and Morris, M. E. Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice. Drug Metab Dispos. 2005;33(3):341-348. View abstract.

Yueh, M. F., Kawahara, M., and Raucy, J. Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes. Toxicol In Vitro 2005;19(2):275-287. View abstract.

Yano, S., Tachibana, H., and Yamada, K. Flavones suppress the expression of the high-affinity IgE receptor FcepsilonRI in human basophilic KU812 cells. J Agric.Food Chem 3-9-2005;53(5):1812-1817. View abstract.

Gyemant, N., Tanaka, M., Antus, S., Hohmann, J., Csuka, O., Mandoky, L., and Molnar, J. In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells. In Vivo 2005;19(2):367-374. View abstract.

Uzel, A., Sorkun, K., Oncag, O., Cogulu, D., Gencay, O., and Salih, B. Chemical compositions and antimicrobial activities of four different Anatolian propolis samples. Microbiol.Res 2005;160(2):189-195. View abstract.

Simons, A. L., Renouf, M., Hendrich, S., and Murphy, P. A. Human gut microbial degradation of flavonoids: structure-function relationships. J Agric.Food Chem 5-18-2005;53(10):4258-4263. View abstract.

Tobin, P. J., Beale, P., Noney, L., Liddell, S., Rivory, L. P., and Clarke, S. A pilot study on the safety of combining chrysin, a non-absorbable inducer of UGT1A1, and irinotecan (CPT-11) to treat metastatic colorectal cancer. Cancer Chemother.Pharmacol 2006;57(3):309-316. View abstract.

Kim, H. J., Lee, S. B., Park, S. K., Kim, H. M., Park, Y. I., and Dong, M. S. Effects of hydroxyl group numbers on the B-ring of 5,7-dihydroxyflavones on the differential inhibition of human CYP 1A and CYP1B1 enzymes. Arch Pharm Res 2005;28(10):1114-1121. View abstract.

Edmunds, K. M., Holloway, A. C., Crankshaw, D. J., Agarwal, S. K., and Foster, W. G. The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells. Reprod.Nutr Dev 2005;45(6):709-720. View abstract.

Moon, Y. J., Wang, X., and Morris, M. E. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro 2006;20(2):187-210. View abstract.

Lyu, S. Y., Rhim, J. Y., and Park, W. B. Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro. Arch Pharm Res 2005;28(11):1293-1301. View abstract.

Cardenas, M., Marder, M., Blank, V. C., and Roguin, L. P. Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines. Bioorg.Med Chem 5-1-2006;14(9):2966-2971. View abstract.

Stipcevic, T., Piljac, J., and Vanden Berghe, D. Effect of different flavonoids on collagen synthesis in human fibroblasts. Plant Foods Hum Nutr 2006;61(1):29-34. View abstract.

Schindler, R. and Mentlein, R. Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cells. J Nutr. 2006;136(6):1477-1482. View abstract.

Lin, C. M., Chang, H., Li, S. Y., Wu, I. H., and Chiu, J. H. Chrysin inhibits lipopolysaccharide-induced angiogenesis via down-regulation of VEGF/VEGFR-2(KDR) and IL-6/IL-6R pathways. Planta Med 2006;72(8):708-714. View abstract.

Kachadourian, R. and Day, B. J. Flavonoid-induced glutathione depletion: potential implications for cancer treatment. Free Radic.Biol.Med. 7-1-2006;41(1):65-76. View abstract.

Gopalakrishnan, A., Xu, C. J., Nair, S. S., Chen, C., Hebbar, V., and Kong, A. N. Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells. Arch Pharm Res 2006;29(8):633-644. View abstract.

Siess, M. H., Le Bon, A. M., Suschetet, M., and Rat, P. Inhibition of ethoxyresorufin deethylase activity by natural flavonoids in human and rat liver microsomes. Food Addit.Contam 1990;7 Suppl 1:S178-S181. View abstract.

Landolfi, R., Mower, R. L., and Steiner, M. Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure-activity relations. Biochem Pharmacol 5-1-1984;33(9):1525-1530. View abstract.

Nose, K. Inhibition by flavonoids of RNA synthesis in permeable WI-38 cells and of transcription by RNA polymerase II. Biochem Pharmacol 12-1-1984;33(23):3823-3827. View abstract.

Conney, A. H., Buening, M. K., Pantuck, E. J., Pantuck, C. B., Fortner, J. G., Anderson, K. E., and Kappas, A. Regulation of human drug metabolism by dietary factors. Ciba Found.Symp. 1980;76:147-167. View abstract.

Tsyrlov, I. B., Mikhailenko, V. M., and Gelboin, H. V. Isozyme- and species-specific susceptibility of cDNA-expressed CYP1A P-450s to different flavonoids. Biochim.Biophys Acta 4-13-1994;1205(2):325-335. View abstract.

Eaton, E. A., Walle, U. K., Lewis, A. J., Hudson, T., Wilson, A. A., and Walle, T. Flavonoids, potent inhibitors of the human P-form phenolsulfotransferase. Potential role in drug metabolism and chemoprevention. Drug Metab Dispos. 1996;24(2):232-237. View abstract.

Collins, B. M., McLachlan, J. A., and Arnold, S. F. The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast. Steroids 1997;62(4):365-372. View abstract.

Kuiper, G. G., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., and Gustafsson, J. A. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998;139(10):4252-4263. View abstract.

Wang, C. and Kurzer, M. S. Effects of phytoestrogens on DNA synthesis in MCF-7 cells in the presence of estradiol or growth factors. Nutr Cancer 1998;31(2):90-100. View abstract.

Campbell, D. R. and Kurzer, M. S. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J.Steroid Biochem.Mol.Biol. 1993;46(3):381-388. View abstract.

Dong D, Quan E, Yuan X, et al. Sodium oleate-based nanoemulsion enhances oral absorption of chrysin through inhibition of UGT-mediated metabolism. Mol Pharm 2016;published online ahead of print. View abstract.

Liu G, Xie W, He AD, et al. Antiplatelet activity of chrysin via inhibiting platelet aIIbß3-mediated signaling pathway. Mol Nutr Food Res 2016;60(9):1984-93. View abstract.

Quan E, Wang H, Dong D, et al. Characterization of chrysin glucuronidation of UGT1A1-overexpressing HeLa cells: elucidating the transporters responsible for efflux of glucuronide. Drug Metab Dispos 2015;43(4):433-43. View abstract.

Samarghandian S, Azimi-Nezhad M, Borji A, et al. Inhibitory and cytotoxic activities of chrysin on human breast adenocarcinoma cells by induction of apoptosis. Pharmacogn Mag 2016;12(Suppl 4):S436-S440. View abstract.

Noh K, Oh do G, Nepal MR, et al. Pharmacokinetic interaction of chrysin with caffeine in rats. Biomol Ther (Seoul) 2016;24(4):446-52. View abstract.

Lim HK, Kim KM, Jeong SY, et al. Chrysin increases the therapeutic efficacy of docetaxel and mitigates docetaxel-induced edema. Integr Cancer Ther 2016;published online ahead of print. View abstract.

Pai SA, Martis EA, Munshi RP, Gursahani MS, Mestry SN, Juvekar AR. Chrysin mitigated obesity by regulating energy intake and expenditure in rats. J Tradit Complement Med 2019;10(6):577-585. View abstract.

Hong JS, Feng JH, Park JS, et al. Antinociceptive effect of chrysin in diabetic neuropathy and formalin-induced pain models. Anim Cells Syst (Seoul) 2020;24(3):143-150. View abstract.

Mohos V, Fliszár-Nyúl E, Ungvári O, et al. Effects of Chrysin and Its Major Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide on Cytochrome P450 Enzymes and on OATP, P-gp, BCRP, and MRP2 Transporters. Drug Metab Dispos 2020;48(10):1064-1073. View abstract.